Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

被引：1104

作者：

Akers, Johnny C. ^{[1
,2
]}

Gonda, David ^{[1
,2
]}

Kim, Ryan ^{[1
,2
]}

Carter, Bob S. ^{[1
,2
]}

Chen, Clark C. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Neurosurg, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Ctr Theoret & Appl Neurooncol, La Jolla, CA 92093 USA

来源：

JOURNAL OF NEURO-ONCOLOGY | 2013年 / 113卷 / 01期

关键词：

Biomarkers; Intracellular trafficking; Membrane budding; Tetraspanin; Multi-vesicular bodies (MVB); Tumor microenvironment; Cancer; HUMAN-ENDOGENOUS-RETROVIRUS; CELL-DERIVED EXOSOMES; HERV-K; PLASMA-MEMBRANE; MULTIVESICULAR-BODY; HUMAN NEUTROPHILS; NUCLEIC-ACIDS; PROTEIN; EXPRESSION; PHOSPHATIDYLSERINE;

D O I：

10.1007/s11060-013-1084-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent studies suggest both normal and cancerous cells secrete vesicles into the extracellular space. These extracellular vesicles (EVs) contain materials that mirror the genetic and proteomic content of the secreting cell. The identification of cancer-specific material in EVs isolated from the biofluids (e.g., serum, cerebrospinal fluid, urine) of cancer patients suggests EVs as an attractive platform for biomarker development. It is important to recognize that the EVs derived from clinical samples are likely highly heterogeneous in make-up and arose from diverse sets of biologic processes. This article aims to review the biologic processes that give rise to various types of EVs, including exosomes, microvesicles, retrovirus like particles, and apoptotic bodies. Clinical pertinence of these EVs to neuro-oncology will also be discussed.

引用

页码：1 / 11

页数：11

共 127 条

[61] APOPTOSIS - BASIC BIOLOGICAL PHENOMENON WITH WIDE-RANGING IMPLICATIONS IN TISSUE KINETICS [J].