Senescence of T Lymphocytes: Implications for Enhancing Human Immunity

被引：206
作者：
Akbar, Arne N. [1 ]
Henson, Sian M. [2 ]
Lanna, Alessio [1 ,3 ]
机构：
[1] UCL, Div Infect & Immun, London, England
[2] Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, London, England
[3] Univ Oxford, Nuffield Dept Med, Oxford, England
来源：
TRENDS IN IMMUNOLOGY | 2016年 / 37卷 / 12期
基金：
英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;
关键词：
P38 MAP KINASE; CELLULAR SENESCENCE; TELOMERE EROSION; RHEUMATOID-ARTHRITIS; SECRETORY PHENOTYPE; CELLS; MEMORY; VIRUS; LENGTH; INFECTION;
D O I：
10.1016/j.it.2016.09.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
As humans live longer, a central concern is to find ways to maintain their health as they age. Immunity declines during ageing, as shown by the increased susceptibility to infection by both previously encountered and new pathogens and by the decreased efficacy of vaccination. It is therefore crucial to understand the mechanisms responsible for this decrease in immunity and to develop new strategies to enhance immune function in older humans. We discuss here how the induction of senescence alters leukocyte, and specifically T cell, function. An emerging concept is that senescence and nutrient sensing-signalling pathways within T cells converge to regulate functional responses, and the manipulation of these pathways may offer new ways to enhance immunity during ageing.
引用
收藏
页码：866 / 876
页数：11
相关论文
共 80 条
[1]   Immunological memory and protective immunity: Understanding their relation [J].
Ahmed, R ;
Gray, D .
SCIENCE, 1996, 272 (5258) :54-60
[2]   Opinion - Will telomere erosion lead to a loss of T-cell memory? [J].
Akbar, AN ;
Beverley, PCL ;
Salmon, M .
NATURE REVIEWS IMMUNOLOGY, 2004, 4 (09) :737-743
[3]   Are senescence and exhaustion intertwined or unrelated processes that compromise immunity? [J].
Akbar, Arne N. ;
Henson, Sian M. .
NATURE REVIEWS IMMUNOLOGY, 2011, 11 (04) :289-295
[4]   CD8+ T cell efficacy in vaccination and disease [J].
Appay, Victor ;
Douek, Daniel C. ;
Price, David A. .
NATURE MEDICINE, 2008, 14 (06) :623-628
[5]   Accelerated immune senescence and HIV-1 infection [J].
Appay, Victor ;
Almeida, Jorge R. ;
Sauce, Delphine ;
Autran, Brigitte ;
Papagno, Laura .
EXPERIMENTAL GERONTOLOGY, 2007, 42 (05) :432-437
[6]   Flow cytometry and FISH to measure the average length of telomeres (flow FISH) [J].
Baerlocher, Gabriela M. ;
Vulto, Irma ;
de Jong, Gary ;
Lansdorp, Peter M. .
NATURE PROTOCOLS, 2006, 1 (05) :2365-2376
[7]   Naturally occurring p16Ink4a-positive cells shorten healthy lifespan [J].
Baker, Darren J. ;
Childs, Bennett G. ;
Durik, Matej ;
Wijers, Melinde E. ;
Sieben, Cynthia J. ;
Zhong, Jian ;
Saltness, Rachel A. ;
Jeganathan, Karthik B. ;
Verzosa, Grace Casaclang ;
Pezeshki, Abdulmohammad ;
Khazaie, Khashayarsha ;
Miller, Jordan D. ;
van Deursen, Jan M. .
NATURE, 2016, 530 (7589) :184-+
[8]   BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice [J].
Baker, DJ ;
Jeganathan, KB ;
Cameron, JD ;
Thompson, M ;
Juneja, S ;
Kopecka, A ;
Kumar, R ;
Jenkins, RB ;
de Groen, PC ;
Roche, P ;
van Deursen, JM .
NATURE GENETICS, 2004, 36 (07) :744-749
[9]   Assessing Cell and Organ Senescence Biomarkers [J].
Bernardes de Jesus, Bruno ;
Blasco, Maria A. .
CIRCULATION RESEARCH, 2012, 111 (01) :97-109
[10]   Immune Memory: the Basics and How to Trigger an Efficient Long-Term Immune Memory [J].
Beverley, P. C. L. .
JOURNAL OF COMPARATIVE PATHOLOGY, 2010, 141 :S91-S95
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