A rational protocol for the synthesis of 1-(2-pyridyl)isoquinolines

被引：16
|
作者：
Kopchuk, Dmitry S. [1 ,2 ]
Kovalev, Igor S. [1 ]
Khasanov, Albert F. [1 ]
Zyryanov, Grigory V. [1 ,2 ]
Slepukhin, Pavel A. [2 ]
Rusinov, Vladimir L. [1 ,2 ]
Chupakhin, Oleg N. [1 ,2 ]
机构：
[1] Ural Fed Univ, Dept Organ Chem, Ekaterinburg 620002, Russia
[2] Russian Acad Sci, Ural Branch, I Ya Postovsky Inst Organ Synth, Ekaterinburg 620990, Russia
来源：
MENDELEEV COMMUNICATIONS | 2013年 / 23卷 / 03期
基金：
俄罗斯基础研究基金会;
关键词：
DIELS-ALDER REACTION; INVERSE ELECTRON DEMAND; ISOQUINOLINE ALKALOIDS; SUBSTITUTED PYRIDINES; ASYMMETRIC-SYNTHESIS; IRIDIUM COMPLEXES; 1,2,4-TRIAZINES; LIGANDS; 2,2'-BIPYRIDINE; CYCLOADDITION;
D O I：
10.1016/j.mencom.2013.05.007
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Aza-Diels-Alder reaction between 3-(2-pyridyl)-1,2,4-triazines and 1-morpholinocyclohexene followed by aromatization of the cyclohexene moiety affords 1-(2-pyridyl)isoquinolines. Crystal structures of two tetrahydroisoquinolines were confirmed by X-ray diffraction analysis.
引用
收藏
页码：142 / 144
页数：3
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