Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer

被引：155

作者：

Lesseur, Corina ^{[1
]}

Diergaarde, Brenda ^{[2
,3
]}

Olshan, Andrew F. ^{[4
,5
]}

Wunsch-Filho, Victor ^{[6
]}

Ness, Andrew R. ^{[7
,8
,9
]}

Liu, Geoffrey ^{[10
]}

Lacko, Martin ^{[11
]}

Eluf-Neto, Jose ^{[12
]}

Franceschi, Silvia ^{[1
]}

Lagiou, Pagona ^{[13
]}

Macfarlane, Gary J. ^{[14
]}

Richiardi, Lorenzo ^{[15
]}

Boccia, Stefania ^{[16
]}

Polesel, Jerry ^{[17
]}

Kjaerheim, Kristina ^{[18
]}

Zaridze, David ^{[19
]}

Johanson, Mattias ^{[1
]}

Menezes, Ana M. ^{[20
]}

Curado, Maria Paula ^{[21
]}

Robinson, Max ^{[22
]}

Ahrens, Wolfgang ^{[23
]}

Canova, Cristina ^{[24
]}

Znaor, Ariana ^{[1
,25
]}

Castellsague, Xavier ^{[26
]}

Conway, David I. ^{[27
,28
]}

Holcatova, Ivana ^{[29
]}

Mates, Dana ^{[30
]}

Vidensky, Marta ^{[31
]}

Healy, Claire M. ^{[32
]}

Szeszenia-Dbrowska, Neonila ^{[33
]}

Fabianova, Eleonora ^{[34
]}

Lissowska, Jolanta ^{[35
,36
]}

Grandis, Jennifer R. ^{[37
,38
]}

Weissler, Mark C. ^{[39
]}

Tajara, Eloiza H. ^{[40
]}

Nunes, Fabio D. ^{[41
]}

de Carvalho, Marcos B. ^{[42
]}

Thomas, Steve ^{[9
]}

Hung, Rayjean J. ^{[43
]}

Peters, Wilbert H. M. ^{[44
]}

Herrero, Rolando ^{[1
]}

Cadoni, Gabriella ^{[45
]}

Bueno-de-Mesquita, H. Bas ^{[46
,47
,48
]}

Steffen, Annika ^{[49
]}

Agudo, Antonio ^{[50
]}

Shangina, Oxana ^{[19
]}

Xiao, Xiangjun ^{[51
]}

Gaborieau, Valerie ^{[1
]}

Chabrier, Amelie ^{[1
]}

Anantharaman, Devasena ^{[1
]}

机构：

[1] Int Agcy Res Canc IARC WHO, Lyon, France

[2] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA

[3] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA

[4] Univ North Carolina Chapel Hill, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA

[5] UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA

[6] Univ Sao Paulo, Fac Saude Publ, Sao Paulo, Brazil

[7] Univ Hosp Bristol NHS Fdn Trust, Natl Inst Hlth Res NIHR Biomed Res Unit Nutr Diet, Bristol, Avon, England

[8] Univ Bristol, Bristol, Avon, England

[9] Univ Bristol, Sch Oral & Dent Sci, Bristol, Avon, England

[10] Princess Margaret Canc Ctr, Toronto, ON, Canada

[11] Maastricht Univ, Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Maastricht, Netherlands

[12] Univ Sao Paulo, Fac Med, Dept Prevent Med, Sao Paulo, Brazil

[13] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece

[14] Univ Aberdeen, Sch Med Med Sci & Nutr, Aberdeen, Scotland

[15] Univ Turin, Dept Med Sci, Turin, Italy

[16] Univ Cattolica Sacro Cuore, Fdn Policlin Agostino Gemelli, Inst Publ Hlth, Sect Hyg, Rome, Italy

[17] CRO Aviano Natl Canc Inst, Canc Epidemiol Unit, Aviano, Italy

[18] Canc Registry Norway, Oslo, Norway

[19] Russian Minist Hlth, NN Blokhin Russian Canc Res Ctr, Inst Carcinogenesis, Dept Canc Epidemiol & Prevent, Moscow, Russia

[20] Univ Fed Pelotas UFPel, Programa Posgrad Epidemiol, Pelotas, Brazil

[21] AC Camargo Canc Ctr, Int Ctr Res CIPE, Epidemiol, Sao Paulo, Brazil

[22] Newcastle Univ, Ctr Oral Hlth Res, Newcastle, England

[23] BIPS, Leibniz Inst Prevent Res & Epidemiol, Bremen, Germany

[24] Univ Padua, Dept Mol Med, Padua, Italy

[25] Croatian Natl Inst Publ Hlth, Zagreb, Croatia

[26] CIBERESP, Inst Catala Oncol, IDIBELL, Barcelona, Spain

[27] Univ Glasgow, Sch Med Dent & Nursing, Glasgow, Lanark, Scotland

[28] NHS Natl Serv Scotland NSS, Edinburgh, Midlothian, Scotland

[29] Charles Univ Prague, Fac Med 1, Inst Hyg & Epidemiol, Prague, Czech Republic

[30] Natl Inst Publ Hlth, Bucharest, Romania

[31] Univ Buenos Aires, Inst Oncol Angel H Roffo, Buenos Aires, DF, Argentina

[32] Trinity Coll Dublin, Sch Dent Sci, Dublin, Ireland

[33] Nofer Inst Occupat Med, Dept Environm Epidemiol, Lodz, Poland

[34] Reg Author Publ Hlth, Banska Bystrica, Slovakia

[35] Maria Sklodowska Curie Mem Canc Ctr, Warsaw, Poland

[36] Inst Oncol MCMCC, Warsaw, Poland

[37] Univ Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA USA

[38] Univ Calif San Francisco, Clin Translat Sci Inst, San Francisco, CA 94143 USA

[39] Univ North Carolina Chapel Hill, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC USA

[40] Sch Med Sao Jose Rio Preto, Dept Mol Biol, Sao Jose Do Rio Preto, Brazil

[41] Univ Sao Paulo, Sch Dent, Dept Stomatol, Sao Paulo, Brazil

[42] Heliopolis Hosp, Dept Head & Neck Surg, Sao Paulo, Brazil

[43] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada

[44] Radboud Univ Nijmegen, Med Ctr, Dept Gastroenterol, Nijmegen, Netherlands

[45] Univ Cattolica Sacro Cuore, Fdn Policlin Agostino Gemelli, Inst Otorhinolaryngol, Rome, Italy

[46] Natl Inst Publ Hlth & Environm RIVM, Dept Determinants & Chron Dis DCD, Bilthoven, Netherlands

[47] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[48] Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia

[49] German Inst Human Nutr Potsdam Rehbruecke DIfE, Nuthetal, Germany

[50] IDIBELL, Inst Catala Oncol, Canc Epidemiol Res Program, Unit Nutr & Canc, Barcelona, Spain

来源：

NATURE GENETICS | 2016年 / 48卷 / 12期

基金：

巴西圣保罗研究基金会; 美国国家卫生研究院;

关键词：

HUMAN-PAPILLOMAVIRUS; NASOPHARYNGEAL CARCINOMA; NECK-CANCER; METAANALYSIS; HEAD; VARIANTS; GENES; PREVALENCE;

D O I：

10.1038/ng.3685

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 x 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 x 10(-9)). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 x 10(-6)) than in HPV-negative (OR = 0.75, P = 0.16) cancers.

引用

页码：1544 / 1550

页数：7

共 50 条

[1] Genome-wide association analyses in east Asians identify new susceptibility loci for colorectal cancer
Jia, Wei-Hua
Zhang, Ben
Matsuo, Keitaro
Shin, Aesun
Xiang, Yong-Bing
Jee, Sun Ha
Kim, Dong-Hyun
Ren, Zefang
Cai, Qiuyin
Long, Jirong
Shi, Jiajun
Wen, Wanqing
Yang, Gong
Delahanty, Ryan J.
Ji, Bu-Tian
Pan, Zhi-Zhong
Matsuda, Fumihiko
Gao, Yu-Tang
Oh, Jae Hwan
Ahn, Yoon-Ok
Park, Eun Jung
Li, Hong-Lan
Park, Ji Won
Jo, Jaeseong
Jeong, Jin-Young
Hosono, Satoyo
Casey, Graham
Peters, Ulrike
Shu, Xiao-Ou
Zeng, Yi-Xin
Zheng, Wei
NATURE GENETICS, 2013, 45 (02) : 191 - 196
[2] Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease
Maguire, Lillias H.
Handelman, Samuel K.
Du, Xiaomeng
Chen, Yanhua
Pers, Tune H.
Speliotes, Elizabeth K.
NATURE GENETICS, 2018, 50 (10) : 1359 - +
[3] A Genome-Wide Association Study Identified Novel Genetic Susceptibility Loci for Oral Cancer in Taiwan
Bau, Da-Tian
Liu, Ting-Yuan
Tsai, Chia-Wen
Chang, Wen-Shin
Gu, Jian
Yang, Jai-Sing
Shih, Liang-Chun
Tsai, Fuu-Jen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (03)
[4] Genome-wide association study of colorectal cancer identifies six new susceptibility loci
Schumacher, Fredrick R.
Schmit, Stephanie L.
Jiao, Shuo
Edlund, Christopher K.
Wang, Hansong
Zhang, Ben
Hsu, Li
Huang, Shu-Chen
Fischer, Christopher P.
Harju, John F.
Idos, Gregory E.
Lejbkowicz, Flavio
Manion, Frank J.
McDonnell, Kevin
McNeil, Caroline E.
Melas, Marilena
Rennert, Hedy S.
Shi, Wei
Thomas, Duncan C.
Van Den Berg, David J.
Hutter, Carolyn M.
Aragaki, Aaron K.
Butterbach, Katja
Caan, Bette J.
Carlson, Christopher S.
Chanock, Stephen J.
Curtis, Keith R.
Fuchs, Charles S.
Gala, Manish
Giocannucci, Edward L.
Gogarten, Stephanie M.
Hayes, Richard B.
Henderson, Brian
Hunter, David J.
Jackson, Rebecca D.
Kolonel, Laurence N.
Kooperberg, Charles
Kury, Sebastian
LaCroix, Andrea
Laurie, Cathy C.
Laurie, Cecelia A.
Lemire, Mathiew
Levine, David
Ma, Jing
Makar, Karen W.
Qu, Conghui
Taverna, Darin
Ulrich, Cornelia M.
Wu, Kana
Kono, Suminori
NATURE COMMUNICATIONS, 2015, 6
[5] Genome-wide association analyses identify two susceptibility loci for pachychoroid disease central serous chorioretinopathy
Hosoda, Yoshikatsu
Miyake, Masahiro
Schellevis, Rosa L.
Boon, Camiel J. F.
Hoyng, Carel B.
Miki, Akiko
Meguro, Akira
Sakurada, Yoichi
Yoneyama, Seigo
Takasago, Yukari
Hata, Masayuki
Muraoka, Yuki
Nakanishi, Hideo
Oishi, Akio
Ooto, Sotaro
Tamura, Hiroshi
Uji, Akihito
Miyata, Manabu
Takahashi, Ayako
Ueda-Arakawa, Naoko
Tajima, Atsushi
Sato, Takehiro
Mizuki, Nobuhisa
Shiragami, Chieko
Iida, Tomohiro
Khor, Chiea Chuen
Wong, Tien Yin
Yamada, Ryo
Honda, Shigeru
de Jong, Eiko K.
den Hollander, Anneke, I
Matsuda, Fumihiko
Yamashiro, Kenji
Tsujikawa, Akitaka
COMMUNICATIONS BIOLOGY, 2019, 2 (1)
[6] Genome-Wide Association Analyses Identify CATSPERE as a Mediator of Colorectal Cancer Susceptibility and Progression
Meng, Yixuan
Du, Mulong
Gu, Dongying
Li, Chen
Li, Shuwei
Zhang, Qiuyi
Ben, Shuai
Zhu, Qiuyuan
Xin, Junyi
Zhang, Zhengdong
Hu, Zhibin
Shen, Hongbing
Jiang, Kewei
Wang, Meilin
CANCER RESEARCH, 2022, 82 (06) : 986 - 997
[7] Genome-wide Association Study of Susceptibility Loci for Cervical Cancer
Chen, Dan
Juko-Pecirep, Ivana
Hammer, Joanna
Ivansson, Emma
Enroth, Stefan
Gustavsson, Inger
Feuk, Lars
Magnusson, Patrik K. E.
McKay, James D.
Wilander, Erik
Gyllensten, Ulf
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2013, 105 (09): : 624 - 633
[8] Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer
Son, Ho-Young
Hwangbo, Yul
Yoo, Seong-Keun
Im, Sun-Wha
Yang, San Duk
Kwak, Soo-Jung
Park, Min Seon
Kwak, Soo Heon
Cho, Sun Wook
Ryu, Jun Sun
Kim, Jeongseon
Jung, Yuh-Seog
Kim, Tae Hyun
Kim, Su-jin
Lee, Kyu Eun
Park, Do Joon
Cho, Nam Han
Sung, Joohon
Seo, Jeong-Sun
Lee, Eun Kyung
Park, Young Joo
Kim, Jong-Il
NATURE COMMUNICATIONS, 2017, 8
[9] Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
Koettgen, Anna
Albrecht, Eva
Teumer, Alexander
Vitart, Veronique
Krumsiek, Jan
Hundertmark, Claudia
Pistis, Giorgio
Ruggiero, Daniela
O'Seaghdha, Conall M.
Haller, Toomas
Yang, Qiong
Tanaka, Toshiko
Johnson, Andrew D.
Kutalik, Zoltan
Smith, Albert V.
Shi, Julia
Struchalin, Maksim
Middelberg, Rita P. S.
Brown, Morris J.
Gaffo, Angelo L.
Pirastu, Nicola
Li, Guo
Hayward, Caroline
Zemunik, Tatijana
Huffman, Jennifer
Yengo, Loic
Zhao, Jing Hua
Demirkan, Ayse
Feitosa, Mary F.
Liu, Xuan
Malerba, Giovanni
Lopez, Lorna M.
van der Harst, Pim
Li, Xinzhong
Kleber, Marcus E.
Hicks, Andrew A.
Nolte, Ilja M.
Johansson, Asa
Murgia, Federico
Wild, Sarah H.
Bakker, Stephan J. L.
Peden, John F.
Dehghan, Abbas
Steri, Maristella
Tenesa, Albert
Lagou, Vasiliki
Salo, Perttu
Mangino, Massimo
Rose, Lynda M.
Lehtimaki, Terho
NATURE GENETICS, 2013, 45 (02) : 145 - 154
[10] Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis
Han, Younghun Y.
Byun, Jinyoung J.
Zhu, Catherine
Sun, Ryan R.
Roh, Julia Y.
Cordell, Heather
Lee, Hyun-Sung A.
Shaw, Vikram R.
Kang, Sung Wook
Razjouyan, Javad
Cooley, Matthew A.
Hassan, Manal M.
Siminovitch, Katherine A.
Folseraas, Trine
Ellinghaus, David
Bergquist, Annika
Rushbrook, Simon M.
Franke, Andre
Karlsen, Tom H.
Lazaridis, Konstantinos N.
McGlynn, Katherine A.
Roberts, Lewis R.
Amos, Christopher, I
Schramm, Christoph
Shapiro, David
Goode, Elizabeth
NATURE COMMUNICATIONS, 2023, 14 (01)

← 1 2 3 4 5 →