Dopaminergic metabolism in carotid bodies and high-altitude acclimatization in female rats

被引:58
作者
Joseph, V
Soliz, J
Soria, R
Pequignot, J [1 ]
Favier, R
Spielvogel, H
Pequignot, JM [1 ]
机构
[1] Univ Lyon 1, Lab Physiol Regulat Energet Cellulaires & Mol, CNRS, UMR 5123, F-69373 Lyon, France
[2] Free Univ Brussels, Hop Erasme, Ctr Etude Rythmes Biol, B-1070 Brussels, Belgium
[3] Univ Zurich Irchel, Inst Physiol, CH-8057 Zurich, Switzerland
[4] Inst Boliviano Biol Altura, La Paz, Bolivia
[5] Univ Lyon 1, Fac Med, UMR 5123, F-69373 Lyon, France
关键词
hypoxia; ovarian steroids; chronic mountain sickness;
D O I
10.1152/ajpregu.00398.2001
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We tested the hypothesis that ovarian steroids stimulate breathing through a dopaminergic mechanism in the carotid bodies. In ovariectomized female rats raised at sea level, domperidone, a peripheral D-2-receptor antagonist, increased ventilation in normoxia (minute ventilation = +55%) and acute hypoxia (+32%). This effect disappeared after 10 daily injections of ovarian steroids (progesterone + estradiol). At high altitude (3,600 m, Bolivian Institute for High-Altitude Biology-IBBA, La Paz, Bolivia), neutered females had higher carotid body tyrosine hydroxylase activity (the rate-limiting enzyme for catecholamine synthesis: +129%) and dopamine utilization (+150%), lower minute ventilation (-30%) and hypoxic ventilatory response (-57%), and higher hematocrit (+18%) and Hb concentration (+21%) than intact female rats. Consistent signs of arterial pulmonary hypertension (right ventricular hypertrophy) also appeared in ovariectomized females. None of these parameters was affected by gonadectomy in males. Our results show that ovarian steroids stimulate breathing by lowering a peripheral dopaminergic inhibitory drive. This process may partially explain the deacclimatization of postmenopausal women at high altitude.
引用
收藏
页码:R765 / R773
页数:9
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