Palladium-Catalyzed Cascade Reactions of 1-(3-Arylprop-2-ynyloxy)-2-bromo Benzene Derivatives with Organoboron Compounds

被引：33

作者：

Arcadi, Antonio ^{[1
]}

Blesi, Federico ^{[1
]}

Cocchi, Sandro ^{[2
]}

Fabrizi, Giancarlo ^{[2
]}

Goggiamani, Antonella ^{[2
]}

Marinelli, Fabio ^{[1
]}

机构：

[1] Univ Aquila, Dipartimento Sci Fis & Chem, I-67010 Coppito, AQ, Italy

[2] Univ Rome, Dipartimento Chim & Tecnol Farm, I-00185 Rome, Italy

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 09期

关键词：

SUZUKI-MIYAURA; STEREOSELECTIVE-SYNTHESIS; COUPLING REACTIONS; DOMINO REACTIONS; H ACTIVATION; CYCLIZATION; INSERTION; ACCESS; CYCLOCARBOPALLADATION; HYDROARYLATION;

D O I：

10.1021/jo400503f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Applications of the cascade cyclocarbopalladation reaction followed by Suzuki-Miyaura coupling reactions of the readily available aryl-substituted propargylic aryl ethers with arylboronic acid and potassium trans-beta-styryltrifluoroborate accomplish a new versatile entry in the synthesis of benzofuran derivatives. Notably, a new approach to the challenging synthesis of C3 functionalized 2-unsubstituted benzofurans has been developed by a cyclocarbopalladation/cross-coupling/aromatization process.

引用

页码：4490 / 4498

页数：9

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