Synthesis of blood compatible polyamide block copolymers

被引：162
|
作者：
Singhal, JP
Ray, AR [1 ]
机构：
[1] Indian Inst Technol, Ctr Biomed Engn, New Delhi 110016, India
[2] All India Inst Med Sci, New Delhi 110029, India
来源：
BIOMATERIALS | 2002年 / 23卷 / 04期
关键词：
hemocompatibility; hemolysis; heparin; polyamide; amidoamine and block copolymer;
D O I：
10.1016/S0142-9612(01)00228-9
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Blood compatibility of polyamides has been improved by introducing amido-amine groups in polymer backbone. Polyamide block-copolymer are synthesized by reacting amine end-capped polyamides with N,N'-methylene-bisacrylamide. Polyamide block-copolymers, thus produced found to have the ability of absorbing heparin. Heparinized polyamide block-copolymers have shown significant improvement in blood compatibility as evident from thrombus formation and hemolysis studies. (C) 2001 Elsevier Science Ltd. All rights reserved.
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页码：1139 / 1145
页数：7
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