Comparison of intralesional verapamil with intralesional triamcinolone in the treatment of hypertrophic scars and keloids

被引:84
作者
Shanthi, F. X. Margaret [1 ]
Ernest, Kalpana [1 ]
Dhanraj, Prema [2 ]
机构
[1] Christian Med Coll & Hosp, Dept Pharmacol & Clin Pharmacol, Vellore 632002, Tamil Nadu, India
[2] Christian Med Coll & Hosp, Dept Plast Surg, Vellore 632002, Tamil Nadu, India
关键词
hypertrophic scar; keloid; triamcinolone; verapamil;
D O I
10.4103/0378-6323.42899
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background : The calcium channel blocker, verapamil stimulates procollagenase synthesis in keloids and hypertrophic scars. Aim : To study the effect of verapamil in the treatment of hypertrophic scars and keloids and to evaluate the effect of verapamil on the rate of reduction of hypertrophic scars and keloids in comparison with triamcinolone. Methods : The study was a randomized, single blind, parallel group study in which 54 patients were allocated to to receive either verapamil or triamcinolone. Drugs were administered intralesionally in both groups. Improvement of the scar was measured using modified Vancouver scale and by using a centimeter scale serially till the scar flattened. Results : There was a reduction in vascularity, pliability, height and width of the scar with both the drugs after 3 weeks of treatment. These changes were present at one year of follow-up after stopping treatment. Scar pigmentation was not changed desirably by either drug. Length of the scars was also not altered significantly by either drug. The rate of reduction in vascularity, pliability, height and width of the scar with triamcinolone was faster than with verapamil. Adverse drug reactions were more with triamcinolone than with verapamil. Conclusion : Intralesional verapamil may be a suitable alternative to triamcinolone in the treatment of hypertrophic scars and keloids.
引用
收藏
页码:343 / 348
页数:6
相关论文
共 20 条
[1]   BIOCHEMICAL-COMPOSITION OF THE CONNECTIVE-TISSUE IN KELOIDS AND ANALYSIS OF COLLAGEN-METABOLISM IN KELOID FIBROBLAST-CULTURES [J].
ABERGEL, RP ;
PIZZURRO, D ;
MEEKER, CA ;
LASK, G ;
MATSUOKA, LY ;
MINOR, RR ;
CHU, ML ;
UITTO, J .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1985, 84 (05) :384-390
[2]  
AHN ST, 1991, ARCH SURG-CHICAGO, V126, P499
[3]   DETERMINING SKIN THICKNESS WITH PULSED ULTRA SOUND [J].
ALEXANDER, H ;
MILLER, DL .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1979, 72 (01) :17-19
[4]  
Baryza Mary Jo, 1995, Journal of Burn Care and Rehabilitation, V16, P535, DOI 10.1097/00004630-199509000-00013
[5]   Recurrence rates of excised keloids treated with postoperative triamcinolone acetonide injections or interferon alfa-2b injections [J].
Berman, B ;
Flores, F .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1997, 37 (05) :755-757
[6]  
Connell P G, 2000, J Cutan Laser Ther, V2, P147
[7]   Combination of surgery and intralesional verapamil of the injection in the treatment of the keloid [J].
Copcu, E ;
Sivrioglu, N ;
Oztan, Y .
JOURNAL OF BURN CARE & REHABILITATION, 2004, 25 (01) :1-7
[8]   Prevention and treatment of keloids with intralesional verapamil [J].
D'Andrea, F ;
Brongo, S ;
Ferraro, G ;
Baroni, A .
DERMATOLOGY, 2002, 204 (01) :60-62
[9]   EVALUATION OF VARIOUS METHODS OF TREATING KELOIDS AND HYPERTROPHIC SCARS - A 10-YEAR FOLLOW-UP-STUDY [J].
DARZI, MA ;
CHOWDRI, NA ;
KAUL, SK ;
KHAN, M .
BRITISH JOURNAL OF PLASTIC SURGERY, 1992, 45 (05) :374-379
[10]   PLASTIC AND RECONSTRUCTIVE SURGERY - SCARS, HYPERTROPHIC SCARS, AND KELOIDS [J].
DAVIES, DM .
BRITISH MEDICAL JOURNAL, 1985, 290 (6474) :1056-1058