Potential new inorganic antitumour agents from combining the anticancer traditional Chinese medicine (TCM) liriodenine with metal ions, and DNA binding studies

被引：59

作者：

Chen, Zhen-Feng ^{[1
]}

Liu, Yan-Cheng ^{[1
,3
]}

Liu, Li-Min ^{[2
]}

Wang, Heng-Shan ^{[1
]}

Qin, San-Hai ^{[2
]}

Wang, Bo-Long ^{[2
]}

Bian, He-Dong ^{[1
]}

Yang, Bin ^{[2
]}

Fun, Hoong-Kun ^{[4
]}

Liu, Hua-Gang ^{[2
]}

Liang, Hong ^{[1
,3
]}

Orvig, Chris ^{[5
]}

机构：

[1] Guangxi Normal Univ, Sch Chem & Chem Engn, Minist Educ, Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China

[2] Guangxi Med Univ, Dept Pharmacol, Nanning 530021, Peoples R China

[3] Nankai Univ, Sch Chem, Tianjin 300071, Peoples R China

[4] Univ Sains Malaysia, Sch Phys, Xray Crystallog Unit, George Town 11800, Malaysia

[5] Univ British Columbia, Dept Chem, Med Inorgan Chem Grp, Vancouver, BC V6T 1Z1, Canada

来源：

DALTON TRANSACTIONS | 2009年 / 02期

基金：

中国国家自然科学基金;

关键词：

RUTHENIUM(II) COMPLEXES; PLATINUM(II) COMPLEXES; CYTOTOXIC ACTIVITY; TOPOISOMERASE-II; FLUORESCENCE; CISPLATIN; DERIVATIVES; INHIBITION; ALKALOIDS; ETHIDIUM;

D O I：

10.1039/b813363h

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Liriodenine (L), an active component of the anticancer traditional Chinese medicine (TCM), was isolated from Zanthoxylum nitidum. Its reactions with Pt(II) and Ru(II) afforded three metal complexes: cis-[PtCl2(L)] (1), cis-[PtCl2(L)(DMSO)] (2), and cis-[RuCl2(L)(DMSO)(2)]center dot 1.5H(2)O (3), the crystal structures of L, 2 and 3 were determined by single-crystal X-ray diffraction methods. These complexes were fully characterized by elemental analysis, IR spectrophotometry, H-1 and C-13 NMR spectroscopies, and ES mass spectrometry. The in vitro cytotoxicity of L and complexes 1-3 against 11 human tumour cell lines was assayed. The metal-based compounds exhibit enhanced cytotoxicity vs. free L, suggesting that these compounds display synergy in the combination of metal ions and liriodenine. The binding properties of L and its complexes 1-3 to ct-DNA were investigated through UV-vis, fluorescence, CD spectra, viscosity and agarose gels electrophoretic measurements.

引用

页码：262 / 272

页数：11

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