In vitro susceptibility of Plasmodium falciparum isolates from gabon to chloroquine and cycloguanil.

被引：0

作者：

Pradines, B ^{[1
]}

Mamfoumbi, MM ^{[1
]}

Keundjian, A ^{[1
]}

Lebeau, C ^{[1
]}

Fusai, T ^{[1
]}

Medang, MO ^{[1
]}

Rogier, C ^{[1
]}

Parzy, D ^{[1
]}

Kombila, M ^{[1
]}

机构：

[1] Inst Trop Med, Serv Sante Armees, Unite Parasitol, F-13007 Marseille, France

来源：

BULLETIN DE LA SOCIETE DE PATHOLOGIE EXOTIQUE | 1999年 / 92卷 / 02期

关键词：

malaria; Plasmodium falciparum; chemosusceptibility; chloroquine-proguanil association; resistance; Libreville; Gabon; central Africa;

D O I：

暂无

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The in vitro susceptibility of 91 Plasmodium falciparum isolates obtained from malaria-infected children living near Libreville (Gabon) was evaluated against chloroquine and cycloguanil (biologically active metabolite of proguanil), using an isotopic micro-drug susceptibility test In vitro resistance to chloroquine and cycloguanil was observed in 83% (35/42) and in 38% (30/78) of the patients, respectively Our data showed that 41% (16/39) of Gabonese field isolates were resistant both to chloroquine and cycloguanil. These findings are of great importance because they might indicate imminent chloroquine-proguanil failure, and there are not many affordable antimalarial drugs to replace chloroquine-proguanil combination.

引用

页码：91 / 94

页数：4

共 44 条

[1] RISK-FACTORS FOR MALARIA AMONG EXPATRIATES LIVING IN KAMPALA, UGANDA - THE NEED FOR ADHERENCE TO CHEMOPROPHYLACTIC REGIMENS [J].

ADERA, T ;

WOLFE, MS ;

MCGUIRERUGH, K ;

CALHOUN, N ;

MARUM, L .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1995, 52 (03) :207-212

[2]

Agnamey P, 1995, B SOC PATHOL EXOT, V88, P149

[3] Chlorproguanil-dapsone: Effective treatment for uncomplicated falciparum malaria [J].

Amukoye, E ;

Winstanley, PA ;

Watkins, WM ;

Snow, RW ;

Hatcher, J ;

Mosobo, M ;

Ngumbao, E ;

Lowe, B ;

Ton, M ;

Minyiri, G ;

Marsh, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (10) :2261-2264

[4]

Anabwani GM, 1996, E AFR MED J, V73, P155

[5] FAILURE OF CHLOROQUINE AND PROGUANIL PROPHYLAXIS IN TRAVELERS TO KENYA [J].

BARNES, AJ ;

ONG, ELC ;

DUNBAR, EM ;

MANDAL, BK ;

WILKINS, EGL .

LANCET, 1991, 338 (8778) :1338-1339

[6] POINT MUTATIONS IN THE DIHYDROFOLATE-REDUCTASE THYMIDYLATE SYNTHASE GENE AND PYRIMETHAMINE AND CYCLOGUANIL RESISTANCE IN PLASMODIUM-FALCIPARUM [J].

BASCO, LK ;

DEPECOULAS, PE ;

WILSON, CM ;

LEBRAS, J ;

MAZABRAUD, A .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1995, 69 (01) :135-138

[7]

BEM JL, 1992, J TROP MED HYG, V95, P167

[8]

BRABIN BJ, 1997, ANN TROP MED PARASIT, V91, P113

[9]

BRANDICOURT O, 1991, TROP MED PARASITOL, V42, P55

[10] SENSITIVITY OF PLASMODIUM-FALCIPARUM TO AMODIAQUINE AND CHLOROQUINE IN CENTRAL-AFRICA - A COMPARATIVE-STUDY IN-VIVO AND IN-VITRO [J].

BRASSEUR, P ;

AGNAMEY, P ;

EKOBO, AS ;

SAMBA, G ;

FAVENNEC, L ;

KOUAMOUO, J .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1995, 89 (05) :528-530

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