miRNA-based biomarkers, therapies, and resistance in Cancer

被引：580
作者：
He, Boxue [1 ,2 ]
Zhao, Zhenyu [1 ,2 ]
Cai, Qidong [1 ,2 ]
Zhang, Yuqian [1 ,2 ]
Zhang, Pengfei [1 ,2 ]
Shi, Shuai [1 ,2 ]
Xie, Hui [1 ,2 ]
Peng, Xiong [1 ,2 ]
Yin, Wei [1 ,2 ]
Tao, Yongguang [1 ,2 ,3 ,4 ,5 ]
Wang, Xiang [1 ,2 ]
机构：
[1] Cent South Univ, Dept Thorac Surg, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China
[2] Cent South Univ, Hunan Key Lab Early Diag & Precis Therapy, Dept Thorac Surg, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China
[3] Cent South Univ, Key Lab Carcinogenesis & Canc Invas, Minist Educ, Dept Pathol,Xiangya Hosp, Changsha 410078, Hunan, Peoples R China
[4] Cent South Univ, NHC Key Lab Carcinogenesis, Canc Res Inst, Changsha 410078, Hunan, Peoples R China
[5] Cent South Univ, Sch Basic Med, Changsha 410078, Hunan, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2020年 / 16卷 / 14期
基金：
中国国家自然科学基金;
关键词：
MicroRNAs; Cancer; miRNA-based biomarkers; miRNA-based therapies; Cancer therapy resistance; HEPATOCELLULAR-CARCINOMA CELLS; MINIMALLY INVASIVE BIOMARKER; RNA-BINDING PROTEINS; NONCODING RNA; POSTTRANSCRIPTIONAL REGULATION; TRANSLATION INITIATION; PROMOTES PROLIFERATION; MICRORNA PRECURSORS; CCR4-NOT COMPLEX; MESSENGER-RNAS;
D O I：
10.7150/ijbs.47203
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in size, play important roles in gene regulation, and their dysregulation is implicated in human diseases including cancer. A variety of miRNAs could take roles in the cancer progression, participate in the process of tumor immune, and function with miRNA sponges. During the last two decades, the connection between miRNAs and various cancers has been widely researched. Based on evidence about miRNA, numerous potential cancer biomarkers for the diagnosis and prognosis have been put forward, providing a new perspective on cancer screening. Besides, there are several miRNA-based therapies among different cancers being conducted, advanced treatments such as the combination of synergistic strategies and the use of complementary miRNAs provide significant clinical benefits to cancer patients potentially. Furthermore, it is demonstrated that many miRNAs are engaged in the resistance of cancer therapies with their complex underlying regulatory mechanisms, whose comprehensive cognition can help clinicians and improve patient prognosis. With the belief that studies about miRNAs in human cancer would have great clinical implications, we attempt to summarize the current situation and potential development prospects in this review.
引用
收藏
页码：2628 / 2647
页数：20
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