EPR investigation of some gamma-irradiated excipients

被引：17
作者：
Aleksieva, Katerina [1 ]
Yordanov, Nicola D. [1 ]
机构：
[1] Bulgarian Acad Sci, Inst Catalysis, BU-1113 Sofia, Bulgaria
来源：
RADIATION EFFECTS AND DEFECTS IN SOLIDS | 2012年 / 167卷 / 09期
关键词：
excipients; gamma-irradiation; EPR; ELECTRON-SPIN-RESONANCE; PARAMAGNETIC-RESONANCE; ESR IDENTIFICATION; RADIATION; DRUGS;
D O I：
10.1080/10420150.2012.684062
中图分类号：
TL [原子能技术]; O571 [原子核物理学];
学科分类号：
0827 ; 082701 ;
摘要：
The results of electron paramagnetic resonance (EPR) studies on some excipients: lactose, microcrystalline cellulose (avicel), starch, dioxosilane (aerosil), talc and magnesium stearate before and after gamma-irradiation are reported. Before irradiation, all samples are EPR silent except talc. After gamma-irradiation, they show complex spectra except magnesium stearate, which is EPR silent. Studies show the influence of gamma-irradiation on EPR spectra and stability of gamma-induced radicals. Analysis of the EPR spectrum of gamma-irradiated talc shows that this material is radiation insensitive. Only lactose forms stable-free radicals upon gamma sterilization and can be used for identification of radiation processing for a long time period thereafter.
引用
收藏
页码：685 / 689
页数：5
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