Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment

被引：136

作者：

Yan, Victoria C. ^{[1
]}

Muller, Florian L. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Canc Syst Imaging, Houston, TX 77054 USA

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2020年 / 11卷 / 07期

关键词：

Prodrug; Covid-19; remdesivir; drug delivery; metabolism; PRODRUG; VIRUS; GS-5734; EBOLA;

D O I：

10.1021/acsmedchemlett.0c00316

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

While remdesivir has garnered much hope for its moderate anti-Covid-19 effects, its parent nucleoside, GS-441524, has been overlooked. Pharmacokinetic analysis of remdesivir evidences premature serum hydrolysis to GS-441524; GS-441524 is the predominant metabolite reaching the lungs. With its synthetic simplicity and in vivo efficacy in the veterinary setting, we contend that GS-441524 is superior to remdesivir for Covid-19 treatment.

引用

页码：1361 / 1366

页数：6

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