An association between affective lability and executive functioning in bipolar disorder

被引：28

作者：

Aminoff, Sofie Ragnhild ^{[1
,2
]}

Jensen, Jimmy ^{[1
,3
]}

Lagerberg, Trine Vik ^{[2
]}

Hellvin, Tone ^{[1
,2
]}

Sundet, Kjetil ^{[2
,4
]}

Andreassen, Ole A. ^{[1
,2
]}

Melle, Ingrid ^{[1
,2
]}

机构：

[1] Univ Oslo, Inst Clin Med, N-0318 Oslo, Norway

[2] Ulleval Hosp, Oslo Univ Hosp, Div Mental Hlth & Addict, Psychosis Res Unit, N-0424 Oslo, Norway

[3] Charite, Dept Psychiat & Psychotherapy, D-13353 Berlin, Germany

[4] Univ Oslo, Fac Social Sci, Dept Psychol, N-0317 Oslo, Norway

来源：

PSYCHIATRY RESEARCH | 2012年 / 198卷 / 01期

关键词：

Verbal fluency; Healthy controls; Depression; First episode mania; SPECTRUM DISORDER; PREVALENCE; MANIA;

D O I：

10.1016/j.psychres.2011.12.044

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Studies suggest altered affect regulation manifested by affective lability in manic/mixed and euthymic states in patients with bipolar disorder (BD). Altered affect regulation may arise from disturbances in interactions between the cognitive and the emotional brain networks. However, the relationship between affective lability and executive function has not previously been studied. Our aim was to investigate affective lability, as measured with the Affective Lability Scale (ALS) in patients with BD (N=32) compared to healthy controls (HC) (N=60), and its relationship to executive functioning. We found significantly higher ALS scores in the BD than in the HC group, indicating a higher degree of affective lability in patients with BD. Subsample analysis revealed a significant positive relationship between affective lability and semantic set shifting abilities in BD only. These findings suggest that higher levels of affective lability compared with controls are a trait as well as state dependent in BD, and that disturbed affective lability may arise from an aberrant interaction between cognitive and emotional brain networks. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：58 / 61

页数：4

共 35 条

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