Free modeling with Rosetta in CASP6

被引：101
作者：
Bradley, P
Malmström, L
Qian, B
Schonbrun, J
Chivian, D
Kim, DE
Meiler, K
Misura, KMS
Baker, D
机构：
[1] Univ Washington, Dept Biochem, Seattle, WA 98195 USA
[2] Vanderbilt Univ, Nashville, TN USA
来源：
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS | 2005年 / 61卷
关键词：
protein structure prediction; fragment insertion; Rosetta; CASP; full-atom refinement;
D O I：
10.1002/prot.20729
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We describe Rosetta predictions in the Sixth Community-Wide Experiment on the Critical Assessment of Techniques for Protein Structure Prediction (CASP), focusing on the free modeling category. Methods developed since CASP5 are described, and their application to selected targets is discussed. Highlights include improved performance on larger proteins (100-200 residues) and the prediction of a 70-residue alpha-beta protein to near-atomic resolution.
引用
收藏
页码：128 / 134
页数：7
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