Platelet-Derived Growth Factor Receptor-Tyrosine Kinase Inhibitor, Imatinib, Is Effective for Treating Pulmonary Hypertension Induced by Pulmonary Tumor Thrombotic Microangiopathy
被引:45
作者:
Minatsuki, Shun
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Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, Japan
Minatsuki, Shun
[1
]
Miura, Ichiro
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机构:
Juntendo Univ, Sch Med, Dept Human Pathol, Tokyo 113, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, Japan
Miura, Ichiro
[2
]
Yao, Atsushi
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Univ Tokyo, Div Hlth Serv Promot, Grad Sch Med, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, Japan
Yao, Atsushi
[3
]
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Abe, Hiroyuki
[4
]
Muraoka, Hironori
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机构:
Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, Japan
Muraoka, Hironori
[1
]
Tanaka, Mariko
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机构:
Univ Tokyo, Dept Pathol, Grad Sch Med, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, Japan
Tanaka, Mariko
[4
]
Imamura, Teruhiko
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机构:
Univ Tokyo, Dept Therapeut Strategy Heart Failure, Grad Sch Med, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, Japan
Imamura, Teruhiko
[5
]
Inaba, Toshiro
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Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, Japan
Inaba, Toshiro
[1
]
Maki, Hisataka
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Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, Japan
Maki, Hisataka
[1
]
Hatano, Masaru
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机构:
Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, Japan
Hatano, Masaru
[1
]
Kinugawa, Koichiro
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机构:
Univ Tokyo, Dept Therapeut Strategy Heart Failure, Grad Sch Med, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, Japan
Kinugawa, Koichiro
[5
]
Yao, Takashi
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机构:
Juntendo Univ, Sch Med, Dept Human Pathol, Tokyo 113, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, Japan
Yao, Takashi
[2
]
Fukayama, Masashi
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机构:
Univ Tokyo, Dept Pathol, Grad Sch Med, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, Japan
Fukayama, Masashi
[4
]
Nagai, Ryozo
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机构:
Jichi Med Univ, Shimotsuke, Tochigi, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, Japan
Nagai, Ryozo
[6
]
Komuro, Issei
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Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, Japan
Komuro, Issei
[1
]
机构:
[1] Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo 1138655, Japan
[2] Juntendo Univ, Sch Med, Dept Human Pathol, Tokyo 113, Japan
[3] Univ Tokyo, Div Hlth Serv Promot, Grad Sch Med, Tokyo 1138655, Japan
[4] Univ Tokyo, Dept Pathol, Grad Sch Med, Tokyo 1138655, Japan
[5] Univ Tokyo, Dept Therapeut Strategy Heart Failure, Grad Sch Med, Tokyo 1138655, Japan
Pulmonary hypertension (PH) induced by pulmonary tumor thrombotic microangiopathy (PTTM) can be fatal because its rapid progression confounds diagnosis, and it is difficult to control with therapy. Here we describe a woman with symptomatic PTTM-PH accompanying gastric cancer that was suspected from perfusion scintigraphy. PTTM-PH was diagnosed by gastroesophageal endoscopy and lung biopsy after partial control of PH using the platelet-derived growth factor (PDGF) receptor (PDGFR) tyrosine kinase inhibitor, imatinib. Treatment with sildenafil and ambrisentan further decreased PH, and she underwent total gastrectomy followed by adjuvant TS-1 chemotherapy. PH did not recur before her death from metastasis. Postmortem histopathology showed recanalized pulmonary arteries where the embolized cancer masses disappeared. PDGF-A, -B, and PDGFR-alpha, beta expression was detected in cancer cells and proliferating pulmonary vascular endothelial cells. Thus, PTTM-PH was successfully controlled using a combination of imatinib, drugs to treat pulmonary arterial hypertension, and cancer management.
机构:
Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, Japan
Hatano, Masaru
Yao, Atsushi
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Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, Japan
Yao, Atsushi
Shiga, Taro
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Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, Japan
Shiga, Taro
Kinugawa, Koichiro
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Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, Japan
Kinugawa, Koichiro
Hirata, Yasunobu
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机构:
Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, Japan
Hirata, Yasunobu
Nagai, Ryozo
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h-index: 0
机构:
Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, Japan
机构:
Univ Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
Hosoya, Yumiko
Watanabe, Masafumi
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机构:
Univ Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
Watanabe, Masafumi
Terashima, Masahiro
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机构:
Univ Tokyo, Cardiovasc Imaging Clin Iidabashi, Tokyo 1138655, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
Terashima, Masahiro
Amiya, Eisuke
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Univ Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
Amiya, Eisuke
Nakao, Tomoko
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Univ Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
Nakao, Tomoko
Hasegawa, Akiko
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机构:
Univ Tokyo, Dept Obstet & Gynecol, Odaira Mem Tokyo Hitachi Hosp, Tokyo 1138655, Japan
Univ Tokyo, Dept Obstet & Gynecol, Tokyo 1138655, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
Hasegawa, Akiko
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Hyodo, Hironobu
Ando, Jiro
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Univ Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
Ando, Jiro
Fujii, Tomoyuki
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机构:
Univ Tokyo, Dept Obstet & Gynecol, Tokyo 1138655, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
Fujii, Tomoyuki
Nagai, Ryozo
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h-index: 0
机构:
Jichi Med Univ, Shimotsuke, Tochigi, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
Nagai, Ryozo
Komuro, Issei
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h-index: 0
机构:
Univ Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
机构:
Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, Japan
Hatano, Masaru
Yao, Atsushi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, Japan
Yao, Atsushi
Shiga, Taro
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, Japan
Shiga, Taro
Kinugawa, Koichiro
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, Japan
Kinugawa, Koichiro
Hirata, Yasunobu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, Japan
Hirata, Yasunobu
Nagai, Ryozo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, JapanUniv Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, Japan
机构:
Univ Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
Hosoya, Yumiko
Watanabe, Masafumi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
Watanabe, Masafumi
Terashima, Masahiro
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Cardiovasc Imaging Clin Iidabashi, Tokyo 1138655, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
Terashima, Masahiro
Amiya, Eisuke
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
Amiya, Eisuke
Nakao, Tomoko
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
Nakao, Tomoko
Hasegawa, Akiko
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Dept Obstet & Gynecol, Odaira Mem Tokyo Hitachi Hosp, Tokyo 1138655, Japan
Univ Tokyo, Dept Obstet & Gynecol, Tokyo 1138655, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
Hasegawa, Akiko
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机构:
Hyodo, Hironobu
Ando, Jiro
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
Ando, Jiro
Fujii, Tomoyuki
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Dept Obstet & Gynecol, Tokyo 1138655, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
Fujii, Tomoyuki
Nagai, Ryozo
论文数: 0引用数: 0
h-index: 0
机构:
Jichi Med Univ, Shimotsuke, Tochigi, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan
Nagai, Ryozo
Komuro, Issei
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, JapanUniv Tokyo, Dept Cardiovasc Med, Grad Sch Med, Tokyo 1138655, Japan