Cu2O-catalyzed tandem ring-opening/coupling cyclization process for the synthesis of 2,3-dihydro-1,4-benzodioxins

被引：60

作者：

Bao, Weiliang ^{[1
]}

Liu, Yunyun ^{[1
]}

Lv, Xin ^{[1
]}

Oian, Weixing ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310028, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 17期

关键词：

D O I：

10.1021/ol801444p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2, 3-Dihydro-1,4-benzodioxins can be prepared in a tandem one-pot procedure by reaction of o-iodophenols with epoxides catalyzed by Cu2O/1,10-phenanthroline/Cs2CO3 system. The reaction is suggested to occur via a novel ring-opening/coupling mechanism, giving moderate to good yields. Moreover, both aryl and aliphatic epoxides are tolerated under these conditions.

引用

页码：3899 / 3902

页数：4

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