Antimicrobial activity of gallium maltolate against Staphylococcus aureus and methicillin-resistant S. aureus and Staphylococcus pseudintermedius: An in vitro study

被引：37

作者：

Arnold, Carolyn E. ^{[1
]}

Bordin, Angela ^{[2
]}

Lawhon, Sara D. ^{[3
]}

Libal, Melissa C. ^{[3
]}

Bernstein, Lawrence R. ^{[4
]}

Cohen, Noah D. ^{[2
]}

机构：

[1] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Large Anim Clin Sci, College Stn, TX 77843 USA

[2] Texas A&M Univ, Coll Vet Med & Biomed Sci, Equine Infect Dis Lab, College Stn, TX 77843 USA

[3] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Pathobiol, College Stn, TX 77843 USA

[4] Terrametrix, Menlo Pk, CA 94025 USA

来源：

VETERINARY MICROBIOLOGY | 2012年 / 155卷 / 2-4期

关键词：

Gallium maltolate; Staphylococcus aureus; Methicillin-resistant Staphylococcus aureus; Staphylococcus pseudintermedius; Methicillin-resistant Staphylococcus pseudintermedius; IRON-METABOLISM; PHARMACOKINETICS;

D O I：

10.1016/j.vetmic.2011.09.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Gallium is a trivalent semi-metallic element that has shown antimicrobial activity against several important human pathogens. This antimicrobial activity is likely related to its substitution in important iron-dependent pathways of bacteria. The genus Staphylococcus, which includes human and animal pathogens that cause significant morbidity and mortality, requires iron for growth and colonization. In this study, gallium maltolate, at various concentrations between 50 and 200 mu M, inhibited the in vitro growth of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) at time-points between 8 and 36 h after inoculation. The inhibitory activity of gallium maltolate against clinical isolates of MRSA and methicillin-resistant Staphylococcus pseudintermedius (MRSP) from a veterinary teaching hospital was determined. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：389 / 394

页数：6

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