The epidemiology of infectious mononucleosis in Northern Scotland: a decreasing incidence and winter peak

被引:15
作者
Visser, Elizabeth [1 ]
Milne, Denis [2 ]
Collacott, Ian [3 ]
McLernon, David [1 ]
Counsell, Carl [4 ]
Vickers, Mark [5 ]
机构
[1] Univ Aberdeen, Coll Life Sci & Med, Div Appl Hlth Sci, Aberdeen AB252ZD, Scotland
[2] Aberdeen Royal Infirm, Dept Haematol, Aberdeen AB25 2ZN, Scotland
[3] Aberdeen Royal Infirm, Dept Virol, Aberdeen AB25 2ZN, Scotland
[4] Univ Aberdeen, Div Appl Hlth Sci, Aberdeen AB25 2ZD, Scotland
[5] Univ Aberdeen, Coll Life Sci & Med, Aberdeen AB25 2ZD, Scotland
基金
英国医学研究理事会;
关键词
Seasonality; Epstein-Barr virus (EBV); Infectious Mononucleosis (IM); Epidemiology; EPSTEIN-BARR-VIRUS; RISK-FACTORS; MULTIPLE-SCLEROSIS; VITAMIN-D; CHILDREN; BIRTH;
D O I
10.1186/1471-2334-14-151
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Infection with Epstein-Barr virus (EBV) is almost ubiquitous in humans and generally occurs at two ages: infantile, which is usually asymptomatic and associated with poorer socioeconomic conditions, and adolescent, which causes infectious mononucleosis (IM) in similar to 25% cases. The determinants of whether the infection causes IM remain uncertain. We aimed to evaluate seasonality and temporal trends in IM. Methods: Data from all Monospot tests, used as a marker for IM, were collected from the Grampian population over 16 years. Results: Positive Monospot test results peaked at 17 years in females and 19 in males. Females had 16% more diagnoses, although 55% more tests. IM was similar to 38% more common in winter than summer. The annual rate of positive tests decreased progressively over the study period, from 174/100 000 (95% CI 171-178) in 1997 to 67/100 000 ( 95% CI 65-69) in 2012. Conclusions: IM appears to be decreasing in incidence, which may be caused by changing environmental influences on immune systems. One such factor may be exposure to sunlight. Words 168.
引用
收藏
页数:8
相关论文
共 43 条
[1]   Vitamin D: The alternative hypothesis [J].
Albert, Paul J. ;
Proal, Amy D. ;
Marshall, Trevor G. .
AUTOIMMUNITY REVIEWS, 2009, 8 (08) :639-644
[2]   Systematic Review and Meta-Analysis of the Sero-Epidemiological Association between Epstein Barr Virus and Multiple Sclerosis [J].
Almohmeed, Yahya H. ;
Avenell, Alison ;
Aucott, Lorna ;
Vickers, Mark A. .
PLOS ONE, 2013, 8 (04)
[3]  
ANDIMAN WA, 1980, MANUAL CLIN IMMUNOLO, P628
[4]   Environmental risk factors for multiple sclerosis. Part I: The role of infection [J].
Ascherio, Alberto ;
Munger, Kassandra L. .
ANNALS OF NEUROLOGY, 2007, 61 (04) :288-299
[5]   Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood:: ISAAC Phases One and Three repeat multicountry cross-sectional surveys [J].
Asher, M. Innes ;
Montefort, Stephen ;
Bjorksten, Bengt ;
Lai, Christopher K. W. ;
Strachan, David P. ;
Weiland, Stephan K. ;
Williams, Hywel .
LANCET, 2006, 368 (9537) :733-743
[6]   INFECTIOUS MONONUCLEOSIS - EPIDEMIOLOGIC PATTERNS AT UNITED-STATES COLLEGES AND UNIVERSITIES [J].
BRODSKY, AL ;
HEATH, CW .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1972, 96 (02) :87-&
[7]   Epidemic influenza and vitamin D [J].
Cannell, J. J. ;
Vieth, R. ;
Umhau, J. C. ;
Holick, M. F. ;
Grant, W. B. ;
Madronich, S. ;
Garland, C. F. ;
Giovannucci, E. .
EPIDEMIOLOGY AND INFECTION, 2006, 134 (06) :1129-1140
[8]   EPSTEIN-BARR VIRUS-INFECTIONS IN A NURSERY [J].
CHANG, RS ;
ROSEN, L ;
KAPIKIAN, AZ .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1981, 113 (01) :22-29
[9]  
Cheng Chia-Chi, 2007, Journal of Microbiology Immunology and Infection, V40, P216
[10]   A cohort study among University students: Identification of risk factors for Epstein-Barr virus seroconversion and infectious mononucleosis [J].
Crawford, DH ;
Macsween, KF ;
Higgins, CD ;
Thomas, R ;
McAulay, K ;
Williams, H ;
Harrison, N ;
Reid, S ;
Conacher, M ;
Douglas, J ;
Swerdlow, AJ .
CLINICAL INFECTIOUS DISEASES, 2006, 43 (03) :276-282