Synthesis and degradation Behaviors of PEO/PL/PEO tri-block copolymers

被引：27

作者：

Lee, SH

Kim, SH

Kim, YH

Han, YK

机构：

[1] Korea Inst Sci & Technol, Biomed Res Ctr, Seoul 130650, South Korea

[2] Hanyang Univ, Dept Chem, Seoul 133791, South Korea

[3] Korea Adv Inst Sci & Technol, Ctr Adv Funct Polymers, Taejon 305701, South Korea

来源：

MACROMOLECULAR RESEARCH | 2002年 / 10卷 / 02期

关键词：

polylactide; poly(ethylene oxide); biodegradable polymer; tri-block copolymer; hydrolytic degradation;

D O I：

10.1007/BF03218295

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Poly(ethylene oxide)/polylatide/poly(ethylene oxide) (PEO/PL/PEO) tri-block copolymers, which each block is connected by ester bond, were synthesized by coupling reaction of PL with PEO in the presence of pyridine. PL/PEO/PL tri-block copolymer was synthesized by ring opening polymerization of L-lactide initiated by PEO in the presence of stannous octoate. Degradation behavior of the copolymers was investigated in a pH 7.4 phosphate buffer saline (PBS) at 37 +/- 1degreesC. Gel permeation chromatography (GPC) and H-1-nuclear magnetic resonance (NMR) were used to monitor the change of mass loss, molecular weight and composition of copolymers. In hydrolytic degradation, the PEO/PL/PEO tri-block copolymer with high PEO contents affected the increase of its mass loss. and resulted in the decrease of its molecular weight as well as PEO composition. However, when PL/PEO/PL and PEO/PL/PEO tri-block copolymers had similar PEO contents, PEO/PL/PEO decreased faster in molecular weight and PEO composition than PL/PEO/PL.

引用

页码：85 / 90

页数：6

共 22 条

[1]

BUTCHER BT, 1982, EUR J RESPIR DIS, V63, P78

[2]

Chen HL, 2000, POLYM ADVAN TECHNOL, V11, P180, DOI 10.1002/1099-1581(200004)11:4<180::AID-PAT965>3.0.CO

[3]

2-C

[4] ABA TYPE COPOLYMERS OF LACTIDE WITH POLY(ETHYLENE GLYCOL) - KINETIC, MECHANISTIC, AND MODEL STUDIES [J].