Neutrophils: Neglected Players in Viral Diseases

被引：15
作者：
Gabriel, Christelle [1 ]
Her, Zhisheng [1 ]
Ng, Lisa F. P. [1 ,2 ]
机构：
[1] ASTAR, Lab Chikungunya Virus Immun, Singapore Immunol Network SIgN, Immunos 138648, Biopolis, Singapore
[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117595, Singapore
来源：
DNA AND CELL BIOLOGY | 2013年 / 32卷 / 12期
关键词：
HUMAN-IMMUNODEFICIENCY-VIRUS; RESPIRATORY SYNCYTIAL VIRUS; INFLUENZA-A VIRUS; CHRONIC GRANULOMATOUS-DISEASE; SIMULTANEOUS QUANTITATIVE-ANALYSIS; HERPES-SIMPLEX-VIRUS; ACUTE LUNG INJURY; POLYMORPHONUCLEAR LEUKOCYTES; CD64; EXPRESSION; BACTERIAL-INFECTION;
D O I：
10.1089/dna.2013.2211
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Increasing evidence has shown that neutrophils are able to crosstalk with various immune cells and have paradoxical roles in pathogen infections. However, the role of neutrophils in viral infections remains poorly defined. Here, the various roles that neutrophils play in viral infections and in host immunity are discussed. Various activation mechanisms of neutrophils following virus interactions and the consequences that affect disease pathogenesis are also addressed. Such knowledge not only could be used in the development of tools for clinical management but would also value-add to the current understanding of innate immunity in viral infections and disease pathogenesis.
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收藏
页码：665 / 675
页数：11
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