Fe-promoted cross coupling of homobenzylic methyl ethers with Grignard reagents via sp3 C-O bond cleavage

被引：36

作者：

Luo, Shuang ^{[1
,2
,3
]}

Yu, Da-Gang ^{[1
,2
,3
]}

Zhu, Ru-Yi ^{[1
,2
,3
]}

Wang, Xin ^{[4
]}

Wang, Lei ^{[4
]}

Shi, Zhang-Jie ^{[1
,2
,3
,5
]}

机构：

[1] Peking Univ, BNLMS, Beijing 100871, Peoples R China

[2] Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Coll Chem, Beijing 100871, Peoples R China

[3] Peking Univ, Green Chem Ctr, Beijing 100871, Peoples R China

[4] Huaibei Normal Univ, Dept Chem, Huaibei 235000, Anhui, Peoples R China

[5] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 71期

关键词：

ALKYL-HALIDES; CATALYZED CARBOMAGNESATION; CONJUGATE ADDITION; EXCHANGE-REACTION; IRON; ALKENES; CARBOMETALATION; ELECTROPHILES; ACTIVATION; COMPLEXES;

D O I：

10.1039/c3cc43616k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first iron-catalyzed formal cross coupling of homobenzylic methyl ethers with alkyl Grignard reagents is realized. The reaction is proposed to proceed through a sequence of dehydroalkoxylation to form the vinyl-intermediate, followed by Fe-catalyzed selective carbometalation to form a benzylic Grignard reagent.

引用

页码：7794 / 7796

页数：3

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