Psoriatic patients undergoing long-term therapy with biologics: Impact of residual localization of psoriasis on quality of life in an Italian clinical setting

被引:6
作者
Muslimani, Muhammad Ali [1 ,2 ]
Bolcato, Vittorio [3 ]
de Silvestri, Annalisa [4 ]
Brazzelli, Valeria [1 ,2 ]
机构
[1] Fdn IRCCS Policlin San Matteo, Inst Dermatol, Pavia, Italy
[2] Univ Pavia, Pavia, Italy
[3] Univ Pavia, Forens Sci Sect Antonio Fornari, Dept Publ Hlth Expt & Forens Med, Pavia, Italy
[4] Fdn IRCCS Policlin San Matteo, Clin Epidemiol & Biometr Unit, Sci Direct, Pavia, Italy
关键词
biologics; difficult-to-treat psoriasis; DLQI; residual psoriasis; treatment-resistant psoriasis; STANDARD; SCALP; AREAS;
D O I
10.1111/dth.14337
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Residual psoriasis characterizes body sites resistant to biologic drugs. Some affected body sites exert disproportionate impact on patients' quality of life. The aim was to localize residual psoriasis in patients treated with biologics for at least 6 months, and to study the correlation between lesional localization and patients' quality of life. Current Psoriasis Area and Severity Index (PASI) and Nail Psoriasis Severity Index (NAPSI) were assessed. Quality of life was obtained by measuring Dermatology Life Quality Index (DLQI). An observational retrospective study was designed. Seventy-five psoriatic patients were included (59 males, 78.67%, mean age 52.45 +/- 11.83 years). The overall median current PASI was 0 (Interquartile Range IQR 0-4). The overall median current NAPSI was 0 (IQR 0-0) and DLQI was 0 (IQR 0-1). The commonest sites of residual psoriasis were elbows (41.33%; 95% confidence interval [CI]: 2.502-38.9), followed by anterior lower legs (33.33%; 95% CI 2.097-23.8) and forearms (29.33%; 95% CI 1.019-10.1). Statistical significance between DLQI and forearm, dorsal hand and abdomen was observed. Sites traditionally regarded as difficult-to-treat were rarely affected by residual lesions and showed relatively limited impact on quality of life.
引用
收藏
页数:5
相关论文
共 15 条
  • [1] Psoriasis
    Boehncke, Wolf-Henning
    Schoen, Michael P.
    [J]. LANCET, 2015, 386 (9997) : 983 - 994
  • [2] Reduced Efficacy of Biological Drugs in Psoriatic Patients with HLA-A Bw4-80I KIR Ligands
    Bolcato, Vittorio
    Pasi, Annamaria
    Cacciatore, Rosalia
    Klersy, Catherine
    Brazzelli, Valeria
    [J]. MOLECULAR DIAGNOSIS & THERAPY, 2020, 24 (03) : 311 - 314
  • [3] Pharmacotherapeutic strategies for standard treatment-resistant psoriasis
    Heath, Michael S.
    Kolli, Sree S.
    Dowling, Jessica R.
    Cline, Abigail
    Feldman, Steven R.
    [J]. EXPERT OPINION ON PHARMACOTHERAPY, 2019, 20 (04) : 443 - 454
  • [4] Localization of treatment-resistant areas in patients with psoriasis on biologics
    Hjuler, K. F.
    Iversen, L.
    Rasmussen, M. K.
    Kofoed, K.
    Skov, L.
    Zachariae, C.
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2019, 181 (02) : 332 - 337
  • [5] Hugh JM, 2018, CUTIS, V102, P6
  • [6] The Dermatology Life Quality Index (DLQI) provides qualitatively different information from the PASI
    Kimball, AB
    Krueger, G
    Woolley, JM
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2004, 50 (03) : P156 - P156
  • [7] Pharmacotherapeutic approaches for treating psoriasis in difficult-to-treat areas
    Kivelevitch, Dario
    Frieder, Jillian
    Watson, Ian
    Paek, So Yeon
    Menter, M. Alan
    [J]. EXPERT OPINION ON PHARMACOTHERAPY, 2018, 19 (06) : 561 - 575
  • [8] Efficacy and safety of adalimumab in difficult-to-treat psoriasis
    Lanna, Caterina
    Zangrilli, Arianna
    Bavetta, Mauro
    Campione, Elena
    Bianchi, Luca
    [J]. DERMATOLOGIC THERAPY, 2020, 33 (03)
  • [9] 10 years experience of the Dermatology Life Quality Index (DLQI)
    Lewis, V
    Finlay, AY
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, 2004, 9 (02) : 169 - 180
  • [10] Guidelines of care for the management of psoriasis and psoriatic arthritis - Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics
    Menter, Alan
    Gottlieb, Alice
    Feldman, Steven R.
    Van Voorhees, Abby S.
    Leonardi, Craig L.
    Gordon, Kenneth B.
    Lebwohl, Mark
    Koo, John Y. M.
    Elmets, Craig A.
    Korman, Neil J.
    Beutner, Karl R.
    Bhushan, Reva
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2008, 58 (05) : 826 - 850