Pharmacodynamics Modeling To Optimize Dosage Regimens of Sulbactam

被引：33

作者：

Jaruratanasirikul, Sutep ^{[1
]}

Wongpoowarak, Wibul ^{[2
]}

Aeinlang, Nanchanit ^{[1
]}

Jullangkoon, Monchana ^{[1
]}

机构：

[1] Prince Songkla Univ, Fac Med, Dept Med, Hat Yai, Songkla, Thailand

[2] Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmaceut Technol, Hat Yai, Songkla, Thailand

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 07期

关键词：

RESISTANT ACINETOBACTER-BAUMANNII; EFFICACY; ANTIBIOTICS; AMPICILLIN; PNEUMONIA; STRAINS; TISSUE;

D O I：

10.1128/AAC.00342-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The aim of this study was to reveal population pharmacokinetics and assess the efficacies of various dosage regimens of sulbactam in terms of the probability of target attainment with this agent over a range of MICs. Monte Carlo simulations were performed to determine the probability of attaining specific pharmacodynamic targets. The results indicated that a regimen consisting of a 4-h infusion of 3 g of sulbactam every 8 h would be an alternative treatment option for less-susceptible pathogens.

引用

页码：3441 / 3444

页数：4

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