The skin microbiome: Current perspectives and future challenges

被引：128

作者：

Chen, Yiyin Erin ^{[1
]}

Tsao, Hensin ^{[2
,3
]}

机构：

[1] Harvard Univ, Sch Med, Med Scientist Training Program, Boston, MA USA

[2] Massachusetts Gen Hosp, Dept Dermatol, Boston, MA 02114 USA

[3] Wellman Ctr Photomed, Boston, MA USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2013年 / 69卷 / 01期

关键词：

antibiotics; atopic dermatitis; Human Microbiome Project; immunology; innate immunity; metagenomics; skin cancer; skin microbiome; RESISTANT STAPHYLOCOCCUS-AUREUS; PLACEBO-CONTROLLED TRIAL; ATOPIC-DERMATITIS; ANTIMICROBIAL PEPTIDES; MOLECULAR ANALYSIS; HELICOBACTER-PYLORI; BACTERIAL BIOTA; PROPIONIBACTERIUM-ACNES; VIRULENCE DETERMINANTS; ANTIBIOTIC-RESISTANCE;

D O I：

10.1016/j.jaad.2013.01.016

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Complex communities of bacteria, fungi, and viruses thrive on our skin. The composition of these communities depends on skin characteristics, such as sebaceous gland concentration, moisture content, and temperature, as well as on host genetics and exogenous environmental factors. Recent metagenomic studies have uncovered a surprising diversity within these ecosystems and have fostered a new view of commensal organisms as playing a much larger role in immune modulation and epithelial health than previously expected. Understanding microbe-host interactions and discovering the factors that drive microbial colonization will help us understand the pathogenesis of skin diseases and develop new promicrobial and antimicrobial therapeutics.

引用

页码：143 / +

页数：16

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