Expression of Lewis X Is Associated With Poor Prognosis in Triple-Negative Breast Cancer

被引：28

作者：

Koh, Young Wha ^{[1
]}

Lee, Hee Jin ^{[1
]}

Ahn, Jin-Hee ^{[2
]}

Lee, Jong Won ^{[3
]}

Gong, Gyungyub ^{[1
]}

机构：

[1] Univ Ulsan, Dept Pathol, Coll Med, Asan Med Ctr, Seoul 138736, South Korea

[2] Univ Ulsan, Dept Oncol, Coll Med, Asan Med Ctr, Seoul 138736, South Korea

[3] Univ Ulsan, Div Breast & Endocrine Surg, Coll Med, Asan Med Ctr, Seoul 138736, South Korea

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2013年 / 139卷 / 06期

关键词：

Triple-negative breast cancer; Lewis X; Prognosis; TRANSITIONAL-CELL-CARCINOMA; LEU-M1; IMMUNOREACTIVITY; ANTIGENS; SSEA-1; WOMEN; PATTERNS; SURVIVAL; STAGE; CD15; IDENTIFICATION;

D O I：

10.1309/AJCP2E6QNDIDPTTC

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The Lewis X (Le(X)) antigen is a prognostic marker in certain solid tumors and has been proposed as a therapeutic target. Immunohistochemical analyses were performed to retrospectively examine the prognostic impact of Le(X) expression in 158 patients with triple-negative breast cancer (TNBC). Twenty-three (14.5%) patients were Leg-positive. Multivariate analysis showed that Le(X) positivity was an independent poor prognostic factor for recurrence-free survival (RFS) and overall survival (OS) (P = .037 and P = .024, respectively). Le(X) expression was a prognostic factor for survival in stage I/II and stage III TNBCs. Subgroup analysis according to age showed that Le(X) positivity was only associated with poor RFS and OS in younger patients with TNBC (age < 50 years) (P < .001 and P < .001, respectively). Our results suggest that Le(X) expression is an independent prognostic factor for RFS and OS in younger patients with TNBC.

引用

页码：746 / 753

页数：8

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