Anti-bacterial activity of inorganic nanomaterials and their antimicrobial peptide conjugates against resistant and non-resistant pathogens

被引:39
作者
Pardhi, Dinesh M. [1 ]
Karaman, Didem Sen [2 ,3 ]
Timonen, Juri [1 ]
Wu, Wei [4 ]
Zhang, Qi [5 ]
Satija, Saurabh [6 ,7 ]
Mehta, Meenu [6 ,7 ]
Charbe, Nitin [8 ]
McCarron, Paul A. [9 ]
Tambuwala, Murtaza M. [9 ]
Bakshi, Hamid A. [9 ]
Negi, Poonam [10 ]
Aljabali, Alaa A. [11 ]
Dua, Kamal [7 ,10 ,12 ,13 ]
Chellappan, Dinesh K. [14 ]
Behera, Ajit [15 ]
Pathak, Kamla [16 ]
Watharkar, Ritesh B. [17 ]
Rautio, Jarkko [1 ]
Rosenholm, Jessica M. [2 ]
机构
[1] Univ Eastern Finland, Fac Hlth Sci, Sch Pharm, POB 1627, FI-70211 Kuopio, Finland
[2] Abo Akad Univ, Fac Sci & Engn, Pharmaceut Sci Lab, Turku 20500, Finland
[3] Izmir Katip Celebi Univ, Fac Engn & Architecture, Biomed Engn Dept, Izmir, Turkey
[4] Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai, Peoples R China
[5] Fudan Univ, Dept Chem, Shanghai, Peoples R China
[6] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India
[7] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Ultimo, NSW 2007, Australia
[8] Pontificia Univ Catolica Chile, Fac Quim, Dept Quim Organ, Av Vicuna McKenna 4860, Santiago 7820436, Chile
[9] Ulster Univ, Sch Pharm & Pharmaceut Sci, Coleraine BT52 1SA, Londonderry, North Ireland
[10] Shoolini Univ Biotechnol & Management Sci, Sch Pharmaceut Sci, Solan, India
[11] Yarmouk Univ, Fac Pharm, Dept Pharmaceut & Pharmaceut Technol, Irbid 566, Jordan
[12] Univ Newcastle, Prior Res Ctr Hlth Lungs, Hunter Med Res Inst HMRI, Callaghan, NSW 230, Australia
[13] Univ Newcastle, Prior Res Ctr Hlth Lungs, Sch Biomed Sci & Pharm, Callaghan, NSW 230, Australia
[14] Int Med Univ, Sch Pharm, Dept Life Sci, Bukit Jalil, Malaysia
[15] Natl Inst Technol, Dept Met & Mat Engn, Rourkela 769008, Odisha, India
[16] Uttar Pradesh Univ Med Sci SAIFAI, Etawah 206130, India
[17] Shramshakti Coll Food Technol, Ahmednagar 422608, Maharashtra, India
基金
芬兰科学院;
关键词
Nanomaterial; Antimicrobial; Conjugates; Antimicrobial peptides; Antibiotics; MESOPOROUS SILICA NANOPARTICLES; GRAM-POSITIVE BACTERIA; HOST-DEFENSE PEPTIDES; IRON-SULFUR CLUSTERS; ONE-POT SYNTHESIS; SILVER NANOPARTICLES; GOLD-NANOPARTICLES; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; ZNO NANOPARTICLES;
D O I
10.1016/j.ijpharm.2020.119531
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This review details the antimicrobial applications of inorganic nanomaterials of mostly metallic form, and the augmentation of activity by surface conjugation of peptide ligands. The review is subdivided into three main sections, of which the first describes the antimicrobial activity of inorganic nanomaterials against gram-positive, gram-negative and multidrug-resistant bacterial strains. The second section highlights the range of antimicrobial peptides and the drug resistance strategies employed by bacterial species to counter lethality. The final part discusses the role of antimicrobial peptide-decorated inorganic nanomaterials in the fight against bacterial strains that show resistance. General strategies for the preparation of antimicrobial peptides and their conjugation to nanomaterials are discussed, emphasizing the use of elemental and metallic oxide nanomaterials. Importantly, the permeation of antimicrobial peptides through the bacterial membrane is shown to aid the delivery of nanomaterials into bacterial cells. By judicious use of targeting ligands, the nanomaterial becomes able to differentiate between bacterial and mammalian cells and, thus, reduce side effects. Moreover, peptide conjugation to the surface of a nanomaterial will alter surface chemistry in ways that lead to reduction in toxicity and improvements in biocompatibility.
引用
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页数:21
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