Lipid segregation and IgE receptor signaling: A decade of progress

被引：108

作者：

Holowka, D ^{[1
]}

Gosse, JA ^{[1
]}

Hammond, AT ^{[1
]}

Han, XM ^{[1
]}

Sengupta, P ^{[1
]}

Smith, NL ^{[1
]}

Wagenknecht-Wiesner, A ^{[1
]}

Wu, M ^{[1
]}

Young, RM ^{[1
]}

Baird, B ^{[1
]}

机构：

[1] Cornell Univ, Dept Chem & Chem Biol, Baker Lab, Ithaca, NY 14853 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2005年 / 1746卷 / 03期

关键词：

lipid raft; immunoreceptor signaling; tyrosine kinase and phosphatase; cytoskeleton; membrane domain;

D O I：

10.1016/j.bbamcr.2005.06.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent work to characterize the roles of lipid segregation in IgE receptor signaling has revealed a mechanism by which segregation of liquid ordered regions from disordered regions of the plasma membrane results in protection of the Src family kinase Lyn from inactivating dephosphorylation by a transmembrane tyrosine phosphatase. Antigen-mediated crosslinking of TgE receptors drives their association with the liquid ordered regions, commonly called lipid rafts, and this facilitates receptor phosphorylation by active Lyn in the raft environment. Previous work showed that the membrane skeleton coupled to F-actin regulates stimulated receptor phosphorylation and downstream signaling processes, and more recent work implicates cytoskeletal interactions with ordered lipid rafts in this regulation. These and other results provide an emerging view of the complex role of membrane structure in orchestrating signal transduction mediated by immune and other cell surface receptors. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：252 / 259

页数：8

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