Acoustic parameters by ultrasonic interferometric measurements of substituted Schiff's bases

In last four decades ultrasonic velocity and density measurement studies created its own importance in medicinal, pharmaceutical, anatomical, biochemical and chemical sciences(1-4). As solute-solvent, solute-solute, solvent-solvent, solute, solvent and metal ion interactions were studied by this techniques, the drug effects, drug actions and drug activity as well as drug absorption were studied by this technique. Hence, taking all these things into consideration, an ultrasonic velocity and density measurements of ligand 2-hydroxy-5-chloro-1-(alpha-p-methylphenylimino)ethyl benzene (L-1), 2-hydroxy3-bromo-5-chloro-1-(alpha-p-methylphenylimino)ethyl benzene (L-2), 2-hydroxy-5-chloro-1-(alpha-p-nitrophenylimino)ethyl benzene (L-3) and 2-hydroxy-5-chloro-1-(alpha-p-chlorophenylimino)ethyl benzene (L-4) were carried out in ethanol, and dioxane solvents. To investigate solute-solvent, solute-solute interactions at 307.15 K. Adiabatic compressibility. (beta), apparent molar compressibility (phi(k)), intermolecular free length (L-f), relative association (R-A), specific acoustic impedance (Z), apparent molar volume (phi(v)) were determined. The effects of various substituents on ligands and solvents on interactions were investigated for drug activity, action and effect of Schiff bases.