Monodispersed Gold Nanoparticles Decorated Carbon Nanotubes as an Enhanced Sensing Platform for Nanomolar Detection of Tramadol

被引：49
作者：
Atta, Nada F. [1 ]
Ahmed, Rasha A. [2 ]
Amin, Hatem M. A. [1 ]
Galal, Ahmed [1 ]
机构：
[1] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt
[2] Taif Univ, Fac Sci, At Taif, Saudi Arabia
来源：
ELECTROANALYSIS | 2012年 / 24卷 / 11期
关键词：
Electrochemical sensor; Carbon nanotubes; Gold nanoparticles; Tramadol; Uric acid; Ascorbic acid; SIMULTANEOUS VOLTAMMETRIC DETERMINATION; COMPOSITE FILM ELECTRODES; LIQUID-LIQUID-EXTRACTION; HUMAN PLASMA; ACETAMINOPHEN; PHARMACOKINETICS; ELECTROCATALYSIS; CHROMATOGRAPHY; GRAPHITE; DOPAMINE;
D O I：
10.1002/elan.201200344
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A promising composite-modified glassy carbon electrode is fabricated by electrodeposition of mono-dispersed gold nanoparticles onto carbon nanotubes (AuNPs/CNTs/GCE). The electroanalysis of Tramadol (TRA) was achieved by different electrochemical techniques. The effect of different parameters including pH, concentration and potential scan on the oxidation current signal of TRA was investigated. Large excess of ascorbic acid (AA) and uric acid (UA) with a maximum molar ratio of 1/1000 and 1/100, respectively, did not interfere with the response of TRA. The detection limit with high sensitivity is 68 nM. TRA was successfully determined in pharmaceutical dosage forms, without any pretreatment of the samples.
引用
收藏
页码：2135 / 2146
页数：12
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