Of the patients randomised to niacin/laropiprant in the HPS-2 THRIVE study, 75% remained compliant after three years of therapy with the combination of an extended-release niacin and the non-flushing agent, laropiprant. HPS-2 THRIVE is a heart-protection study focused on treating high-density lipoprotein (HDL) cholesterol to reduce the incidence of vascular events.