Topical Delivery of Steroids in Inflammatory Bowel Disease

被引：9
作者：
Girlich, C. [1 ]
Schoelmerich, J. [2 ]
机构：
[1] Univ Regensburg, Dept Internal Med 1, D-93042 Regensburg, Germany
[2] Goethe Univ Frankfurt, D-60590 Frankfurt, Germany
来源：
CURRENT DRUG DELIVERY | 2012年 / 9卷 / 04期
关键词：
Steroids; inflammatory bowel disease; DISTAL ULCERATIVE-COLITIS; ILEAL RELEASE CAPSULES; ACTIVE CROHNS-DISEASE; BECLOMETHASONE DIPROPIONATE; ORAL BUDESONIDE; 5-AMINOSALICYLIC ACID; MAINTENANCE TREATMENT; RETENTION ENEMAS; DOUBLE-BLIND; EC CAPSULES;
D O I：
10.2174/156720112801323071
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Crohn's disease (CD) and ulcerative colitis (UC) represent two similar but probably not uniform entities of inflammatory bowel disease (IBD). Since up to now no curative treatment is available the therapeutic goal in active IBD is elimination or at least alleviation of symptoms and maintenance of remission. Glucocorticoids have been successfully used in the treatment of symptoms and inflammation. Due to the minor systemic side effects a topical drug delivery targeting the active substances directly to the inflamed sites would be the favorable administration. In this review the use of topical corticosteroids is discussed, based on a short description of their pharmacological properties.
引用
收藏
页码：345 / 349
页数：5
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