Long-term outcomes of patients with Streptococcus suis infection in Viet Nam: A case-control study

被引：14

作者：

Huong, Vu T. L. ^{[1
,2
]}

Long, Hoang B. ^{[1
]}

Kinh, Nguyen V. ^{[3
]}

Ngan, Ta T. D. ^{[3
]}

Dung, Vu T. V. ^{[1
]}

Nadjm, Behzad ^{[1
,2
]}

van Doorn, H. Rogier ^{[1
,2
]}

Hoa, Ngo T. ^{[2
,4
,5
]}

Horby, Peter ^{[1
,2
]}

Wertheim, Heiman F. L. ^{[1
,2
,6
]}

机构：

[1] Wellcome Trust Major Overseas Programme, Oxford Univ Clin Res Unit, 78 Giai Phong, Hanoi, Vietnam

[2] Univ Oxford, Nuffield Dept Med, Oxford OX1 3BD, England

[3] Natl Hosp Trop Dis, 78 Giai Phong, Hanoi, Vietnam

[4] Wellcome Trust Major Overseas Programme, Oxford Univ Clin Res Unit, 764 Vo Van Kiet, Ho Chi Minh, Vietnam

[5] Univ Sci Natl Univ, Dept Biol & Biotechnol, Ho Chi Minh, Vietnam

[6] Radboud UMC, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands

来源：

JOURNAL OF INFECTION | 2018年 / 76卷 / 02期

基金：

英国惠康基金;

关键词：

Streptococcus suis; Hearing loss; Vestibular dysfunction; Bacterial meningitis; Long-term outcomes; HEARING IMPAIRMENT; PREVALENCE; MENINGITIS; COMMUNITY; SAMPLE; ADULTS;

D O I：

10.1016/j.jinf.2017.09.019

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives: Streptococcus suis is a zoonotic cause of severe meningitis and sepsis in humans. We aimed to assess the long-term outcomes in patients who survived S. suis infection, in particular the progress and impact of vestibulocochlear sequelae. Methods: This case-control study evaluated outcomes of S. suis infection at discharge and 3 and 9 months post-discharge for 47 prospectively enrolled cases and at 11-34 months for 31 retrospectively enrolled cases. Outcomes in patients were compared to 270 controls matched for age, sex and residency. Results: The prevalence ratio (PR) of moderate-to-complete hearing loss was 5.0(95% CI 3.6-7.1) in cases at discharge, 3.7(2.5-5.4) at 3 months, 3.2(2.2-4.7) at 9 months, and 3.1(2.1-4.4) in retrospective cases compared to controls. Hearing improvement occurred mostly within the first 3 months with a change in hearing level of 11.1%(95% CI 7.0-15.1%) compared to discharge. The PR of vestibular dysfunction was 2.4(95% CI 1.7-3.3) at discharge, 2.2(1.4-3.1) at 3 months, 1.8(1.1-2.5) at 9 months, and 1.8(1.1-2.6) for retrospective cases compared to controls. Cases also indicated more problems with mobility, self-care and usual activities. Conclusions: Both hearing and vestibular impairment were common and persist in cases. Appropriate patient management strategies are needed to reduce the incidence and impact of these sequelae. (C) 2017 The Authors. Published by Elsevier Ltd on behalf of The British Infection Association.

引用

页码：159 / 167

页数：9

共 29 条

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