Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase

被引：51
作者：
Gan, YR [1 ]
Huang, H
Huang, YD
Rao, CM
Zhao, Y
Liu, JS
Wu, L
Wei, DQ
机构：
[1] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China
[2] Natl Inst Control Pharmaceut & Biol Prod, Beijing 100050, Peoples R China
[3] TIBDD, Tianjin 300074, Peoples R China
[4] Tianjin Normal Univ, Tianjin 300074, Peoples R China
来源：
PEPTIDES | 2006年 / 27卷 / 04期
关键词：
SARS; coronavirus proteinase; octapeptide AVLQSGFR; Chou's distorted key" theory;
D O I：
10.1016/j.peptides.2005.09.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The outbreak of SARS, a life-threatening disease, has spread over many countries around the world. So far there is no effective drug for the treatment of SARS. Stimulated by the binding mechanism of SARS-CoV M-pro with the octapeptide AVLQSGFR reported recently as well as the "Chou's distorted key" theory, we synthesized the octapeptide AVLQSGFR for conducting various biochemical experiments to investigate the antiviral potential of the octapeptide against SARS coronavirus (BJ-01). The results demonstrate that, compared with other compounds reported so far, AVLQSGFR is the most active in inhibiting replication of and that no detectable toxicity is observed on Vero cells under the the SARS coronavirus, condition of experimental concentration. (c) 2005 Elsevier Inc. All rights reserved.
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收藏
页码：622 / 625
页数：4
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