Intraperitoneal cisplatin and doxorubicin as maintenance chemotherapy for unresectable ovarian cancer: a case report

被引：17

作者：

Tempfer, Clemens B. ^{[1
]}

Hartmann, Franziska ^{[2
]}

Hilal, Ziad ^{[1
]}

Rezniczek, Guenther A. ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Dept Obstet & Gynecol, Bochum, Germany

[2] Ruhr Univ Bochum, Dept Pathol, Bochum, Germany

来源：

BMC CANCER | 2017年 / 17卷

关键词：

Ovarian cancer; Intraperitoneal chemotherapy; Maintenance; Peritoneal carcinomatosis; PIPAC; Quality of life; Antineoplastic agents; Adverse effects; PHASE-II TRIAL; AEROSOL CHEMOTHERAPY; PRIMARY SURGERY; VINORELBINE; RECURRENT; OXALIPLATIN; GEMCITABINE; SURVIVAL; PIPAC;

D O I：

10.1186/s12885-016-3004-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Primary advanced, unresectable ovarian cancer (OC) is treated with palliative systemic chemotherapy. Intraperitoneal chemotherapy may be an alternative local maintenance therapy. Case presentation: A 75 year old woman with laparoscopically and histologically confirmed unresectable OC was treated with 13 cycles of intraperitoneal cisplatin 7.5 mg/m(2) and doxorubicin 1.5 mg/m(2) over 2 years using laparoscopic pressurized intraperitoneal aerosol chemotherapy (PIPAC). Objective tumor response (tumor regression on histology, stable disease on repeated video-laparoscopy and peritoneal carcinomatosis index) was noted. No Common Terminology Criteria for Adverse Events (CTCAE) > grade 3 were observed. EORTC QLQ-C30 quality of life measurements were stable throughout the therapy. Conclusions: Repeated intraperitoneal chemotherapy with cisplatin and doxorubicin applied as PIPAC may be an effective maintenance treatment in women with primary advanced, unresectable OC.

引用

页数：6

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