Efficient synthesis of IPL576,092: A novel anti-asthma agent

被引：46
作者：
Shen, Y [1 ]
Burgoyne, DL [1 ]
机构：
[1] Inflazyme Pharmaceut Ltd, Richmond, BC V6V 2M2, Canada
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 11期
关键词：
D O I：
10.1021/jo0108717
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An enantioseletive synthesis of the novel anti-asthma agent IRL576,092 (2) is described. The synthetic route developed involves stereoselective 1,2-reduction of the enone carbonyl functionality of 6 and subsequent hydroboration as the key steps. Starting from the commercially available 5-androsten-3beta-ol-17-one 3, this approach affords IPL576,092 (2) in nine steps with overall yields of 25%, employing a limited number of chromatographic steps.
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页码：3908 / 3910
页数：3
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