LEFT VENTRICULAR LONGITUDINAL STRAIN AND STRAIN RATE MEASURED BY 2-D SPECKLE TRACKING ECHOCARDIOGRAPHY IN NEONATES DURING WHOLE-BODY HYPOTHERMIA

被引:24
作者
Czernik, Christoph [1 ]
Rhode, Stefanie [1 ]
Helfer, Sven [1 ]
Schmalisch, Gerd [1 ]
Buehrer, Christoph [1 ]
机构
[1] Charite Univ Med Ctr, Dept Neonatol, Berlin, Germany
关键词
Asphyxia; Newborn infant; 2-D strain; HYPOXIC-ISCHEMIC ENCEPHALOPATHY; CARDIAC TROPONIN-T; MILD HYPOTHERMIA; PERINATAL ASPHYXIA; THERAPEUTIC HYPOTHERMIA; SYSTEMIC HYPOTHERMIA; MODERATE HYPOTHERMIA; INFANTS; DOPPLER; PERFORMANCE;
D O I
10.1016/j.ultrasmedbio.2013.03.024
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
The purpose of the study was to assess changes in cardiac performance in newborn infants with hypoxicischemic encephalopathy during therapeutic hypothermia and rewarming with two-dimensional speckle tracking echocardiography. For eight asphyxiated neonates (median birth weight (range): 3038 (2725-3253) g; umbilical artery pH: 6.9 (6.8-7.18) undergoing whole-body hypothermia (33-34 degrees C), left ventricular longitudinal strain and strain rate, as well as heart rate, cardiac output and left ventricular fractional shortening, were determined at four points in time: the start (T1) and end of hypothermia (T2), immediately after rewarming (T3) and the age of 5 to 7 d (T4). Mean (standard deviation) heart rate increased from 93 (12) beats/min at T1 to 133 (12) beats/min at T4 (p < 0.001). Cardiac output was low during hypothermia (T1: 207 [43] mL/kg/min, T2: 240 [70] mL/kg/min) and increased significantly (p < 0.001) afterward (T3: 329 [70] mL/kg/min, T4: 388 [78] mL/kg/min). Left ventricular fractional shortening remained unchanged. Left ventricular global longitudinal peak systolic strain did not differ significantly between hypothermia and rewarming, whereas the systolic strain rate increased from -1.1 (0.3) s(-1) at T1 to -1.8 (0.26) s(-1) at T4 (p = 0.001). Hypothermia affects peak systolic strain rate, heart rate and cardiac output, with complete recovery after rewarming, whereas peak systolic strain and fractional shortening remain stable. (E-mail: christoph.czernik@charite.de) (C) 2013 World Federation for Ultrasound in Medicine & Biology.
引用
收藏
页码:1343 / 1349
页数:7
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