Hydrazide-hydrazones as potential antimicrobial agents: overview of the literature since 2010

被引：259

作者：

Popiolek, Lukasz ^{[1
]}

机构：

[1] Med Univ Lublin, Dept Organ Chem, Fac Pharm, 4A Chodzki St, PL-20093 Lublin, Poland

来源：

MEDICINAL CHEMISTRY RESEARCH | 2017年 / 26卷 / 02期

关键词：

Hydrazide-hydrazone; Antibacterial activity; Antitubercular activity; Antifungal activity; MIC; DERIVATIVES; DESIGN; ANTIMYCOBACTERIAL; NITROFURANTOIN; ANTIBACTERIAL; MECHANISM; COUMARIN; PYRIDINE;

D O I：

10.1007/s00044-016-1756-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Hydrazide-hydrazone derivatives are present in many bioactive molecules and display a wide variety of biological activities, such as antibacterial, antitubercular, antifungal, anticancer, anti-inflammatory, anticonvulsant, antiviral, and antiprotozoal action. Therefore, many medicinal chemists synthesize various hydrazide-hydrazones and evaluate them for biological activities. Among biological properties of this class of compounds, antimicrobial activity is the most frequently encountered in scientific literature. This paper is focused on the overview of the literature findings of the last six years (2010-2016) covering the research on antimicrobial activity of hydrazide-hydrazone derivatives. This review may also serve as a useful guide for the development of new hydrazide-hydrazones as potential antimicrobial agents.

引用

页码：287 / 301

页数：15

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