Pt(II) compounds interplay with Cu(II) and Zn(II) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease

被引：60

作者：

Collin, Fabrice ^{[1
]}

Sasaki, Isabelle ^{[2
,3
]}

Eury, Helene ^{[2
,3
]}

Faller, Peter ^{[2
,3
]}

Hureau, Christelle ^{[2
,3
]}

机构：

[1] Univ Toulouse 3, PHARMA DEV, UMR IRD UPS 152, F-31400 Toulouse, France

[2] CNRS, LCC, F-31077 Toulouse, France

[3] Univ Toulouse, UPS, INPT, LCC, F-31077 Toulouse, France

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 21期

关键词：

BINDING; ZINC; INHIBITORS; AGENTS; IONS;

D O I：

10.1039/c3cc38537j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Five Pt(II) complexes were tested for their ability to interfere in Cu(II) or Zn(II) coordination to the A beta peptide. Two of them induce modifications of the Cu(II) sphere but not the associated Cu(A beta) ROS production. In contrast, they do completely preclude Zn induced A beta aggregation.

引用

页码：2130 / 2132

页数：3

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