Biotransformation and Enzymatic Reactions of Synthetic Pyrethroids in Mammals

被引：39

作者：

Mikata, Kazuki ^{[1
]}

Isobe, Naohiko ^{[1
]}

Kaneko, Hideo ^{[1
]}

机构：

[1] Sumitomo Chem Co Ltd, Environm Hlth Sci Lab, Konohana Ku, Osaka 5548558, Japan

来源：

PYRETHROIDS: FROM CHRYSANTHEMUM TO MODERN INDUSTRIAL INSECTICIDE | 2012年 / 314卷

关键词：

Carboxylesterase; CYP; Ester hydrolysis; Metabolism; Oxidation; Pyrethroid; IN-VITRO METABOLISM; 3-PHENOXYBENZOIC ACID; CYTOCHROME-P450; ISOFORMS; DIFFERENTIAL METABOLISM; HUMAN CARBOXYLESTERASES; HYDROLYTIC METABOLISM; TETRAMETHRIN ISOMERS; GRANULOMA-FORMATION; SPECIES-DIFFERENCES; RISK ASSESSMENT;

D O I：

10.1007/128_2011_254

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthetic pyrethroids, a major insecticide group, are used worldwide for controlling indoor and agricultural pests. Extensive mammalian metabolism studies have been carried out since the late 1960s, and major metabolic reactions have been found to be oxidation of the acid or alcohol moiety, ester cleavage, and conjugation reactions. In addition, various conjugation reactions occur in mammals, forming hydrophilic and lipophilic conjugates. Pyrethroids are generally rapidly metabolized in mammals and completely excreted from the body in a short period. Human and laboratory animals share similar metabolic reactions for pyrethroids. Oxidation reactions in humans are mediated by several CYP isoforms. On the other hand, ester bonds of pyrethroids are hydrolyzed mainly by carboxylesterase(s).

引用

页码：113 / 135

页数：23

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