Selene: a PyTorch-based deep learning library for sequence data

被引:87
作者
Chen, Kathleen M. [1 ]
Cofer, Evan M. [2 ,3 ]
Zhou, Jian [1 ,2 ]
Troyanskaya, Olga G. [1 ,2 ,4 ]
机构
[1] Simons Fdn, Flatiron Inst, New York, NY 10010 USA
[2] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA
[3] Princeton Univ, Grad Program Quantitat & Computat Biol, Princeton, NJ 08544 USA
[4] Princeton Univ, Dept Comp Sci, Princeton, NJ 08544 USA
关键词
DNA;
D O I
10.1038/s41592-019-0360-8
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
To enable the application of deep learning in biology, we present Selene (https://selene.flatironinstitute.org/), a PyTorch-based deep learning library for fast and easy development, training, and application of deep learning model architectures for any biological sequence data. We demonstrate on DNA sequences how Selene allows researchers to easily train a published architecture on new data, develop and evaluate a new architecture, and use a trained model to answer biological questions of interest.
引用
收藏
页码:315 / +
页数:6
相关论文
共 21 条
  • [1] Predicting the sequence specificities of DNA- and RNA-binding proteins by deep learning
    Alipanahi, Babak
    Delong, Andrew
    Weirauch, Matthew T.
    Frey, Brendan J.
    [J]. NATURE BIOTECHNOLOGY, 2015, 33 (08) : 831 - +
  • [2] DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning
    Angermueller, Christof
    Lee, Heather J.
    Reik, Wolf
    Stegle, Oliver
    [J]. GENOME BIOLOGY, 2017, 18
  • [3] Avsec Z., 2018, BIORXIV, DOI [10.1101/375345v1, DOI 10.1101/375345V1]
  • [4] pysster: classification of biological sequences by learning sequence and structure motifs with convolutional neural networks
    Budach, Stefan
    Marsico, Annalisa
    [J]. BIOINFORMATICS, 2018, 34 (17) : 3035 - 3037
  • [5] Opportunities and obstacles for deep learning in biology and medicine
    Ching, Travers
    Himmelstein, Daniel S.
    Beaulieu-Jones, Brett K.
    Kalinin, Alexandr A.
    Do, Brian T.
    Way, Gregory P.
    Ferrero, Enrico
    Agapow, Paul-Michael
    Zietz, Michael
    Hoffman, Michael M.
    Xie, Wei
    Rosen, Gail L.
    Lengerich, Benjamin J.
    Israeli, Johnny
    Lanchantin, Jack
    Woloszynek, Stephen
    Carpenter, Anne E.
    Shrikumar, Avanti
    Xu, Jinbo
    Cofer, Evan M.
    Lavender, Christopher A.
    Turaga, Srinivas C.
    Alexandari, Amr M.
    Lu, Zhiyong
    Harris, David J.
    DeCaprio, Dave
    Qi, Yanjun
    Kundaje, Anshul
    Peng, Yifan
    Wiley, Laura K.
    Segler, Marwin H. S.
    Boca, Simina M.
    Swamidass, S. Joshua
    Huang, Austin
    Gitter, Anthony
    Greene, Casey S.
    [J]. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2018, 15 (141)
  • [6] An integrated encyclopedia of DNA elements in the human genome
    Dunham, Ian
    Kundaje, Anshul
    Aldred, Shelley F.
    Collins, Patrick J.
    Davis, CarrieA.
    Doyle, Francis
    Epstein, Charles B.
    Frietze, Seth
    Harrow, Jennifer
    Kaul, Rajinder
    Khatun, Jainab
    Lajoie, Bryan R.
    Landt, Stephen G.
    Lee, Bum-Kyu
    Pauli, Florencia
    Rosenbloom, Kate R.
    Sabo, Peter
    Safi, Alexias
    Sanyal, Amartya
    Shoresh, Noam
    Simon, Jeremy M.
    Song, Lingyun
    Trinklein, Nathan D.
    Altshuler, Robert C.
    Birney, Ewan
    Brown, James B.
    Cheng, Chao
    Djebali, Sarah
    Dong, Xianjun
    Dunham, Ian
    Ernst, Jason
    Furey, Terrence S.
    Gerstein, Mark
    Giardine, Belinda
    Greven, Melissa
    Hardison, Ross C.
    Harris, Robert S.
    Herrero, Javier
    Hoffman, Michael M.
    Iyer, Sowmya
    Kellis, Manolis
    Khatun, Jainab
    Kheradpour, Pouya
    Kundaje, Anshul
    Lassmann, Timo
    Li, Qunhua
    Lin, Xinying
    Marinov, Georgi K.
    Merkel, Angelika
    Mortazavi, Ali
    [J]. NATURE, 2012, 489 (7414) : 57 - 74
  • [7] A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease
    Huang, Kuan-lin
    Marcora, Edoardo
    Pimenova, Anna A.
    Di Narzo, Antonio F.
    Kapoor, Manav
    Jin, Sheng Chih
    Harari, Oscar
    Bertelsen, Sarah
    Fairfax, Benjamin P.
    Czajkowski, Jake
    Chouraki, Vincent
    Grenier-Boley, Benjamin
    Bellenguez, Celine
    Deming, Yuetiva
    McKenzie, Andrew
    Raj, Towfique
    Renton, Alan E.
    Budde, John
    Smith, Albert
    Fitzpatrick, Annette
    Bis, Joshua C.
    DeStefano, Anita
    Adams, Hieab H. H.
    Ikram, M. Arfan
    van der Lee, Sven
    Del-Aguila, Jorge L.
    Fernandez, Maria Victoria
    Ibanez, Laura
    Sims, Rebecca
    Escott-Price, Valentina
    Mayeux, Richard
    Haines, Jonathan L.
    Farrer, Lindsay A.
    Pericak-Vance, Margaret A.
    Lambert, Jean Charles
    van Duijn, Cornelia
    Launer, Lenore
    Seshadri, Sudha
    Williams, Julie
    Amouyel, Philippe
    Schellenberg, Gerard D.
    Zhang, Bin
    Borecki, Ingrid
    Kauwe, John S. K.
    Cruchaga, Carlos
    Hao, Ke
    Goate, Alison M.
    [J]. NATURE NEUROSCIENCE, 2017, 20 (08) : 1052 - +
  • [8] Sequential regulatory activity prediction across chromosomes with convolutional neural networks
    Kelley, David R.
    Reshef, Yakir A.
    Bileschi, Maxwell
    Belanger, David
    McLean, Cory Y.
    Snoek, Jasper
    [J]. GENOME RESEARCH, 2018, 28 (05) : 739 - 750
  • [9] Basset: learning the regulatory code of the accessible genome with deep convolutional neural networks
    Kelley, David R.
    Snoek, Jasper
    Rinn, John L.
    [J]. GENOME RESEARCH, 2016, 26 (07) : 990 - 999
  • [10] Integrative analysis of 111 reference human epigenomes
    Kundaje, Anshul
    Meuleman, Wouter
    Ernst, Jason
    Bilenky, Misha
    Yen, Angela
    Heravi-Moussavi, Alireza
    Kheradpour, Pouya
    Zhang, Zhizhuo
    Wang, Jianrong
    Ziller, Michael J.
    Amin, Viren
    Whitaker, John W.
    Schultz, Matthew D.
    Ward, Lucas D.
    Sarkar, Abhishek
    Quon, Gerald
    Sandstrom, Richard S.
    Eaton, Matthew L.
    Wu, Yi-Chieh
    Pfenning, Andreas R.
    Wang, Xinchen
    Claussnitzer, Melina
    Liu, Yaping
    Coarfa, Cristian
    Harris, R. Alan
    Shoresh, Noam
    Epstein, Charles B.
    Gjoneska, Elizabeta
    Leung, Danny
    Xie, Wei
    Hawkins, R. David
    Lister, Ryan
    Hong, Chibo
    Gascard, Philippe
    Mungall, Andrew J.
    Moore, Richard
    Chuah, Eric
    Tam, Angela
    Canfield, Theresa K.
    Hansen, R. Scott
    Kaul, Rajinder
    Sabo, Peter J.
    Bansal, Mukul S.
    Carles, Annaick
    Dixon, Jesse R.
    Farh, Kai-How
    Feizi, Soheil
    Karlic, Rosa
    Kim, Ah-Ram
    Kulkarni, Ashwinikumar
    [J]. NATURE, 2015, 518 (7539) : 317 - 330