THz Medical Imaging: in vivo Hydration Sensing

被引：293

作者：

Taylor, Zachary D. ^{[1
,2
]}

Singh, Rahul S. ^{[2
,5
]}

Bennett, David B. ^{[2
,3
]}

Tewari, Priyamvada ^{[1
,2
]}

Kealey, Colin P. ^{[2
,4
]}

Bajwa, Neha ^{[1
,2
]}

Culjat, Martin O. ^{[2
,5
]}

Stojadinovic, Alexander ^{[7
,8
]}

Lee, Hua ^{[9
]}

Hubschman, Jean-Pierre ^{[6
]}

Brown, Elliott R. ^{[10
]}

Grundfest, Warren S. ^{[2
,11
]}

机构：

[1] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, CASIT, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Dept Surg, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Dept Surg, Dept Bioengn, Los Angeles, CA 90095 USA

[6] Univ Calif Los Angeles, Dept, Los Angeles, CA 90095 USA

[7] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA

[8] Combat Wound Initiat Program, Washington, DC 20307 USA

[9] Univ Calif Santa Barbara, Dept Elect & Comp Engn, Santa Barbara, CA 93106 USA

[10] Wright State Univ, Dept Phys, Dayton, OH 45435 USA

[11] Univ Calif Los Angeles, Dept Elect Engn, Dept Bioengn, Dept Surg, Los Angeles, CA 90095 USA

来源：

IEEE TRANSACTIONS ON TERAHERTZ SCIENCE AND TECHNOLOGY | 2011年 / 1卷 / 01期

基金：

美国国家科学基金会;

关键词：

Biological and medical imaging; clinical instruments; hydration interactions; medical diagnostics; submillimeter; Terahertz; THz; TERAHERTZ PULSED SPECTROSCOPY; SKIN-CANCER; REFLECTION SPECTROSCOPY; PHOTOCONDUCTIVE SWITCH; LIQUID WATER; EX-VIVO; TIME; PERMITTIVITY; TEMPERATURE; SCATTERING;

D O I：

10.1109/TTHZ.2011.2159551

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

The application of THz to medical imaging is experiencing a surge in both interest and federal funding. A brief overview of the field is provided along with promising and emerging applications and ongoing research. THz imaging phenomenology is discussed and tradeoffs are identified. A THz medical imaging system, operating at similar to 525 GHz center frequency with similar to 125 GHz of response normalized bandwidth is introduced and details regarding principles of operation are provided. Two promising medical applications of THz imaging are presented: skin burns and cornea. For burns, images of second degree, partial thickness burns were obtained in rat models in vivo over an 8 hour period. These images clearly show the formation and progression of edema in and around the burn wound area. For cornea, experimental data measuring the hydration of ex vivo porcine cornea under drying is presented demonstrating utility in ophthalmologic applications.

引用

页码：201 / 219

页数：19

共 141 条

[1] FUCHS ENDOTHELIAL DYSTROPHY OF THE CORNEA [J].

ADAMIS, AP ;

FILATOV, V ;

TRIPATHI, BJ ;

TRIPATHI, RC .

SURVEY OF OPHTHALMOLOGY, 1993, 38 (02) :149-168

[2]

American Burn Association, BURN INC TREATM US 2

[3]

Anastasi R. F., 2006, INT WORKSH ULTR ADV

[4]

[Anonymous], NAT BURN REP

[5]

[Anonymous], 2008, AIP CONF P

[6]

Arbab M. H., 2011, SPIE ADV BIOMEDICAL

[7]

Arnone D, 2000, PHYS WORLD, V13, P35

[8] Applications of Terahertz (THz) technology to medical imaging [J].

Arnone, DD ;

Ciesla, CM ;

Corchia, A ;

Egusa, S ;

Pepper, M ;

Chamberlain, JM ;

Bezant, C ;

Linfield, EH ;

Clothier, R ;

Khammo, N .

TERAHERTZ SPECTROSCOPY AND APPLICATIONS 11, 1999, 3828 :209-219

[9] Terahertz pulsed spectroscopy of freshly excised human breast cancer [J].

Ashworth, Philip C. ;

Pickwell-MacPherson, Emma ;

Provenzano, Elena ;

Pinder, Sarah E. ;

Purushotham, Anand D. ;

Pepper, Michael ;

Wallace, Vincent P. .

OPTICS EXPRESS, 2009, 17 (15) :12444-12454

[10] State of the art in burn treatment [J].

Atiyeh, BS ;

Gunn, SW ;

Hayek, SN .

WORLD JOURNAL OF SURGERY, 2005, 29 (02) :131-148

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