The Speed of Progression to Tobacco and Alcohol Dependence: A Twin Study

被引：13
作者：
Huggett, Spencer B. [1 ,2 ]
Hatoum, Alexander S. [1 ,2 ]
Hewitt, John K. [1 ,2 ]
Stallings, Michael C. [1 ,2 ]
机构：
[1] Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA
[2] Univ Colorado, Inst Behav Genet, 1480 30th St, Boulder, CO 80303 USA
来源：
BEHAVIOR GENETICS | 2018年 / 48卷 / 02期
关键词：
Tobacco; Alcohol; Twins; Genetics; Age of initiation; Dependence; ADOLESCENT SUBSTANCE USE; AGE-OF-ONSET; POPULATION-BASED SAMPLE; ENVIRONMENTAL-INFLUENCES; SMOKING INITIATION; NICOTINE DEPENDENCE; CIGARETTE-SMOKING; DRUG-USE; GENDER-DIFFERENCES; RAPID PROGRESSION;
D O I：
10.1007/s10519-018-9888-0
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
We investigated the etiological role of genetic and environmental influences for two milestones of tobacco and alcohol use: age of initiation, and speed of progression to dependence (latency). Study participants included 1352 monozygotic and 1422 dizygotic twins (mean age at assessment = 24.31). Earlier ages of initiation significantly increased the likelihood of developing dependence, but were associated with longer dependence latencies for tobacco and alcohol. Latencies to dependence were heritable traits for tobacco (a (2) = 0.63) and alcohol (a (2) = 0.64). Genetic influences contributing to early age of initiation were associated with faster latencies to dependence but sometimes were counteracted by environmental factors, the extent to which depended on substance and, sometimes, sex. Our findings may have important implications for public policy and add to the literature by characterizing the genetic and environmental contributions to the speed of progression to tobacco and alcohol dependence.
引用
收藏
页码：109 / 124
页数：16
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