Cell Membrane Bioconjugation and Membrane-Derived Nanomaterials for Immunotherapy

被引:43
作者
Li, Peter Y. [1 ]
Fan, Zhiyuan [1 ]
Cheng, Hao [1 ]
机构
[1] Drexel Univ, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA
基金
美国国家卫生研究院;
关键词
T-CELLS; PANCREATIC-ISLETS; DENDRITIC CELLS; DRUG-DELIVERY; POLYMERIC NANOPARTICLES; ANTIGEN PRESENTATION; IMMUNE-RESPONSES; CANCER; TOLERANCE; SURVIVAL;
D O I
10.1021/acs.bioconjchem.7b00669
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Cell membrane engineering, including live cell membrane bioconjugation and cell membrane-derived nanomaterials is a highly promising strategy to modulate immune responses for treating diseases. Many cell membrane engineering methods have potential for translation for human clinical use in the near future. In this Topical Review, we summarize the cell membrane conjugation strategies that have been investigated for cancer immunotherapy, the prevention of immune rejection to donor cells and tissues, and the induction of antigen-specific tolerance in autoimmune diseases. Additionally, cell membrane-derived or membrane-coated nanomaterials are an emerging class of nanomaterials that is attracting significant attention in the field of nanomedicine. Some of these nanomaterials have been employed to elicit immune responses against cancer, toxins, and bacteria, although their application in establishing immune tolerance has not been explored. In addition to discussing potential problems, we provide our perspectives for promising future directions.
引用
收藏
页码:624 / 634
页数:11
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