A comprehensive assessment of single nucleotide polymorphisms associated with pancreatic cancer risk A protocol for systematic review and network meta-analysis

被引：2
作者：
Ye, Zhuo-Miao [1 ]
Li, Li-Juan [2 ]
Zheng, Jing-Hui [3 ]
Zhang, Chi [4 ]
Lu, Yun-Xin [5 ]
Tang, Youming [6 ]
机构：
[1] Guangxi Univ Chinese Med, Ruikang Sch Clin Med, Nanning, Peoples R China
[2] Guangxi Univ Chinese Med, Clin Fac 1, Nanning, Peoples R China
[3] Guangxi Univ Chinese Med, Ruikang Hosp, Dept Cardiol, Nanning 530011, Peoples R China
[4] Guangxi Univ Chinese Med, Grad Sch, Nanning, Peoples R China
[5] Guangxi Univ Chinese Med, Ruikang Hosp, Dept Oncol, Nanning, Peoples R China
[6] Guangxi Univ Chinese Med, Ruikang Hosp, Dept Gastroenterol, Nanning, Peoples R China
来源：
MEDICINE | 2020年 / 99卷 / 24期
关键词：
case-control study; model of inheritance; network meta-analysis; pancreatic cancer; susceptibility; GENE; VARIANTS; SUSCEPTIBILITY;
D O I：
10.1097/MD.0000000000020345
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Single nucleotide polymorphisms (SNPs) have been inconsistently associated with pancreatic cancer (PC) risk. This meta-analysis aimed to synthesize relevant data on SNPs associated with PC. Methods: Databases were searched to identify association studies of SNPs and PC published through January 2020 from the databases of PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure, the Chinese Science and Technology Periodical Database (VIP) and Wanfang databases. Network meta-analysis and Thakkinstian algorithm were used to select the most appropriate genetic model, along with false positive report probability (FPRP) for noteworthy associations. The methodological quality of data was assessed based on the STREGA statement Stata 14.0 will be used for systematic review and meta-analysis. Results: This study will provide a high-quality evidence to find the SNP most associated with pancreatic cancer susceptibility and the best genetic model. Conclusions: This study will explore which SNP is most associated with pancreatic cancer susceptibility. Registration: INPLASY202040023.
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页数：4
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