Carapanolides A and B: unusual 9,10-seco-mexicanolides having a 2R,9S-oxygen bridge from the seeds of Carapa guianensis

被引：25

作者：

Inoue, Takanobu ^{[1
]}

Nagai, Yumi ^{[1
]}

Mitooka, Aya ^{[1
]}

Ujike, Reina ^{[1
]}

Muraoka, Osamu ^{[2
]}

Yamada, Takeshi ^{[1
]}

Tanaka, Reiko ^{[1
]}

机构：

[1] Osaka Univ Pharmaceut Sci, Takatsuki, Osaka 5691094, Japan

[2] Kinki Univ, Fac Pharmaceut Sci, Higashiosaka, Osaka 5778502, Japan

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 49期

关键词：

Carapanolides A and B; 9,10-seco-Mexicanolide-2,9-oxide; Carapa guianensis; Seed; Limonoid; L1210; MANGROVE XYLOCARPUS-GRANATUM; AUBLET MELIACEAE; TETRANORTRITERPENOIDS; LIMONOIDS; HEARTWOOD; TOXICITY; OIL;

D O I：

10.1016/j.tetlet.2012.09.108

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel limonoids, named carapanolides A (1) and B (2) were isolated from the seeds of Carapa guianensis A(UBLET) (Meliaceae), a traditional medicine in Brazil and Latin American countries. Their structures elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques were quite unusual, bearing 2,9-oxygen bridge in the 9,10-seco-mexicanolide skeleton. Compound 1 showed moderate activity against L1210 cell line. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：6685 / 6688

页数：4

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