Stereoselective synthesis of quaternary proline analogues

被引：103

作者：

Calaza, M. Isabel ^{[1
]}

Cativiela, Carlos ^{[1
]}

机构：

[1] Univ Zaragoza, Dept Quim Organ, Inst Ciencia Mat Aragon, CSIC, E-50009 Zaragoza, Spain

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 2008卷 / 20期

关键词：

alpha; alpha-disubstituted amino acids; constrained amino acids; alpha-substituted prolines; diastercoselectivity; enantio selectivity;

D O I：

10.1002/ejoc.200800225

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This review describes available methods for the diastereoselective and asymmetric synthesis of quaternary prolines. The focus is on the preparation of alpha-functionalized prolines in which the pyrrolidine moiety is not embedded in a polycyclic frame. The diverse synthetic approaches are classified according to the bond that is formed to complete the quaternary skeleton. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).

引用

页码：3427 / 3448

页数：22

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