New Use for Old Drugs: The Protective Effect of Risperidone on Colorectal Cancer

被引：14

作者：

Chen, Vincent Chin-Hung ^{[1
,2
]}

Hsieh, Yi-Hsuan ^{[2
,3
]}

Lin, Tzu-Chin ^{[4
]}

Lu, Mong-Liang ^{[5
,6
]}

Liao, Yin-To ^{[7
]}

Yang, Yao-Hsu ^{[8
,9
,10
]}

Hsu, Tsai-Ching ^{[11
,12
,13
]}

Stewart, Robert ^{[14
,15
]}

Weng, Jun-Cheng ^{[1
,16
]}

Lee, Min-Jing ^{[1
]}

Chiu, Wei-Che ^{[17
,18
]}

Tzang, Bor-Show ^{[11
,12
,13
,19
]}

机构：

[1] Chang Gung Mem Hosp, Dept Psychiat, Puzi 61363, Chiayi, Taiwan

[2] Chang Gung Univ, Sch Med, Taoyuan 33302, Taiwan

[3] Chang Gung Mem Hosp Taoyuan, Dept Child Psychiat, Taoyuan 33305, Taiwan

[4] Bethel Psychiat Clin, Taipei 11074, Taiwan

[5] Taipei Med Univ, Wan Fang Hosp, Dept Psychiat, Taipei 11696, Taiwan

[6] Taipei Med Univ, Coll Med, Sch Med, Dept Psychiat, Taipei 11042, Taiwan

[7] Chung Shan Med Univ, Chung Shan Med Univ Hosp, Dept Psychiat, Taichung 40201, Taiwan

[8] Chang Gung Mem Hosp, Hlth Informat & Epidemiol Lab, Puzi 61363, Chiayi, Taiwan

[9] Chang Gung Mem Hosp, Dept Tradit Chinese Med, Puzi 61363, Chiayi, Taiwan

[10] Chang Gung Univ, Coll Med, Sch Tradit Chinese Med, Taoyuan 33302, Taiwan

[11] Chung Shan Med Univ Hosp, Clin Lab, Taichung 40201, Taiwan

[12] Chung Shan Med Univ, Inst Biochem Microbiol & Immunol, Taichung 40201, Taiwan

[13] Chung Shan Med Univ, Immunol Res Ctr, Taichung 40201, Taiwan

[14] Kings Coll London, Inst Psychiat Psychol & Neurosci, London WC2R 2LS, England

[15] South London & Maudsley NHS Fdn Trust, London SE5 8AZ, England

[16] Chang Gung Univ, Dept Med Imaging & Radiol Sci, Taoyuan 33302, Taiwan

[17] Cathay Gen Hosp, Dept Psychiat, Taipei 10686, Taiwan

[18] Fu Jen Catholic Univ, Coll Med, Sch Med, New Taipei 24257, Taiwan

[19] Chung Shan Med Univ, Sch Med, Dept Biochem, Taichung 40201, Taiwan

来源：

CANCERS | 2020年 / 12卷 / 06期

基金：

英国工程与自然科学研究理事会; 英国医学研究理事会;

关键词：

antipsychotics; colorectal cancer; Taiwan National Health Insurance; risperidone; SW480; ADENOCARCINOMA; SCHIZOPHRENIA; RISK;

D O I：

10.3390/cancers12061560

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

(1) Background: The potential of old drugs in novel indications is being greatly valued. We propose a triple-model study involving population-based, cell, and animal studies to investigate the effects of risperidone, a type of second-generation antipsychotic (SGA) drug, on colorectal cancer. (2) Methods: We used data from Taiwan's National Health Insurance Research Database between 1997 and 2013 to compare 101,989 patients with colorectal cancer and 101,989 controls. Conditional logistic regression analyses were used to explore the association between SGA exposure and the risk of colorectal cancer. The following bench studies were performed to evaluate the findings of the population-based study. (3) Results: We found that SGAs had been less commonly used in colorectal cancer patients than in controls. The colorectal cancer risk was reduced with an increase in the cumulative defined daily dose (cDDD) of SGAs. The adjusted odds ratio of antipsychotic use for cDDD days was 0.32 (95% CI: 0.25-0.42). Risperidone exhibited the most prominent tumor inhibition effect in a cell screen study. Bench data revealed that risperidone significantly induced apoptosis and elevated intracellular ROS in human SW480 cells and suppressed the proliferation of the xenografted SW480 tumor in nude mice. (4) Conclusion: This triple-model study demonstrates the association between risperidone usage and a lower risk of colorectal cancer.

引用

页码：1 / 16

页数：16

共 27 条

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