Nitro-fatty acids as novel electrophilic ligands for peroxisome proliferator-activated receptors

被引：13
作者：
Ferreira, Ana M. [2 ]
Minarrieta, Lucia [2 ]
Lamas Bervejillo, Maria [2 ]
Rubbo, Homero [1 ,3 ]
机构：
[1] Univ Republica, Fac Med, Dept Bioquim, Montevideo 11800, Uruguay
[2] Univ Republica, Fac Ciencias Quim, Catedra Inmunol, Montevideo 11800, Uruguay
[3] Univ Republica, Fac Med, Ctr Free Rad & Biomed Res, Montevideo 11800, Uruguay
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2012年 / 53卷 / 09期
关键词：
Nitro-fatty acids; Peroxisome proliferator-activated receptors; Inflammation; Lipid metabolism; Free radicals; PPAR-GAMMA; NITROLINOLEIC ACID; HUMAN BLOOD; KAPPA-B; OXIDE; NITRATION; PROTEIN; AGONISTS; BINDING; GLUTATHIONE;
D O I：
10.1016/j.freeradbiomed.2012.08.572
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lipid nitration has been observed during oxidative/nitrative stress conditions generating a variety of biomolecules capable of modulating cellular responses. This concept has grown as a result of studies with nitro-derivatives of long-chain unsaturated fatty acids containing a nitroalkene group (nitro-fatty acids). This review focuses on the interactions of nitro-fatty acids with members of the peroxisome proliferator-activated receptors (PPARs) family. These nuclear receptors belong to a superfamily of ligand-activated transcription factors, which serve as sensors of lipophilic molecules and regulate the expression of a set of genes involved in glucose and lipid metabolism. Here we discuss how nitro-fatty acids bind and activate PPARs, including the current knowledge of the molecular interactions and cell signaling events involved as well as their therapeutic potential associated with chronic inflammation and metabolic disorders. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：1654 / 1663
页数：10
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