Total Synthesis of (-)-Isoschizogamine

被引：48

作者：

Miura, Yusuke ^{[1
]}

Hayashi, Noriyuki ^{[1
]}

Yokoshima, Satoshi ^{[1
]}

Fukuyama, Tohru ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 29期

基金：

日本学术振兴会;

关键词：

AUS SCHIZOZYGIA CAFFAEOIDES; 1,4-DIPOLAR CYCLOADDITION; ORGANIC-SYNTHESIS; ISOSCHIZOGAMINE; METATHESIS; EFFICIENT; REAGENTS; (+/-)-ISOSCHIZOGAMINE; EXPLORATIONS; CATALYSTS;

D O I：

10.1021/ja305856q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A first asymmetric total synthesis of (-)-isoschizogamine has been accomplished. Our synthesis features the facile construction of the carbon framework of the natural product through a Wagner-Meerwein rearrangement, a tandem metathesis, a stereo-selective rhodium-mediated 1,4-addition of an arylboronic acid, and a ring-closing metathesis via a hemiaminal ether.

引用

页码：11995 / 11997

页数：3

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